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Nevanac Generic Name & Formulations
Legal Class
Rx
General Description
Nepafenac 0.1%, oph. susp; contains benzalkonium chloride.
Pharmacological Class
NSAID.
How Supplied
Susp—3mL
Manufacturer
Mechanism of Action
After topical ocular dosing, nepafenac penetrates the cornea and is converted by ocular tissue hydrolases to amfenac, an NSAID. Amfenac is thought to inhibit the action of prostaglandin H synthase (cyclooxygenase), an enzyme required for prostaglandin production.
Nevanac Indications
Indications
Post-operative pain and inflammation following cataract surgery.
Nevanac Dosage and Administration
Adult
≥10yrs: 1 drop in affected eye(s) 3 times daily starting one day before surgery, continued on day of surgery, and through first 2 weeks post-op.
Children
<10yrs: not established.
Nevanac Contraindications
Not Applicable
Nevanac Boxed Warnings
Not Applicable
Nevanac Warnings/Precautions
Warnings/Precautions
Bleeding tendencies. May delay wound healing. Complicated/repeat ocular surgeries. Corneal defects/denervation. Ocular surface diseases. Rheumatoid arthritis. Diabetes. Monitor cornea; discontinue if corneal epithelial breakdown occurs. Risk of corneal adverse events may be increased if used more than 24 hours before surgery, or beyond 14 days post-op. Contact lenses (remove during therapy). Pregnancy (Cat.C; avoid during 3rd trimester). Nursing mothers.
Nevanac Pharmacokinetics
Elimination
Renal.
Nevanac Interactions
Interactions
Caution with concomitant medications that may prolong bleeding time. Increased potential for healing problems with concomitant topical steroids.
Nevanac Adverse Reactions
Adverse Reactions
Ocular effects (eg, capsular opacity, decreased visual acuity, foreign body sensation, increased intraocular pressure, sticky sensation, edema, dry eye, lid margin crusting, discomfort, hyperemia, pain, pruritus, photophobia, tearing, vitreous detachment), headache, hypertension, GI upset, sinusitis.
Nevanac Clinical Trials
See Literature
Nevanac Note
Not Applicable
Nevanac Patient Counseling
See Literature
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