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Istalol Generic Name & Formulations
Legal Class
Rx
General Description
Timolol (as maleate) 0.5%; oph soln; contains benzalkonium chloride.
Pharmacological Class
Noncardioselective beta-blocker.
How Supplied
Soln—5mL
Manufacturer
Istalol Indications
Indications
Open-angle glaucoma. Ocular hypertension.
Istalol Dosage and Administration
Adult
1 drop in affected eye(s) once daily in the AM.
Children
Not recommended.
Istalol Contraindications
Contraindications
Greater than 1st-degree AV block. Overt cardiac failure. Cardiogenic shock. Sinus bradycardia. Bronchial asthma. Severe COPD. History of bronchospasm. Not for use as a sole agent in angle-closure glaucoma.
Istalol Boxed Warnings
Not Applicable
Istalol Warnings/Precautions
Warnings/Precautions
History of cardiac failure. Discontinue at 1st sign of cardiac failure, and before surgery. Avoid abrupt cessation. Diabetes. May mask hypoglycemia, thyrotoxicosis. Myasthenia gravis. Cerebrovascular insufficiency. Contact lenses (remove; may reinsert 15 min after instillation). Pregnancy (Cat.C). Nursing mothers: not recommended.
Istalol Pharmacokinetics
See Literature
Istalol Interactions
Interactions
Avoid other topical β-blockers. May potentiate systemic β-blockers, reserpine, hypoglycemics, and mydriatic effect of topical epinephrine. May be potentiated by quinidine. May cause conduction defects with digoxin, calcium channel blockers (avoid concomitant use in impaired cardiac function).
Istalol Adverse Reactions
Adverse Reactions
Local irritation (burning, stinging), blurred vision, cataract, conjunctival injection, infection, headache, hypertension, itching. Systemic β-blocker effects (eg, bronchospasm, bradycardia, cardiac failure, muscle weakness).
Istalol Clinical Trials
See Literature
Istalol Note
Not Applicable
Istalol Patient Counseling
See Literature
