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Epinastine Hcl Generic Name & Formulations
Legal Class
Rx
General Description
Epinastine HCl 0.05%; oph soln; contains benzalkonium chloride.
Pharmacological Class
Antihistamine.
How Supplied
Contact supplier
Manufacturer
Mechanism of Action
Epinastine is a topically active, direct H1-receptor antagonist and an inhibitor of the release of histamine from the mast cell. Epinastine is selective for the histamine H1-receptor and has affinity for the histamine H2-receptor. Epinastine also possesses affinity for the α1, α2-, and 5-HT2–receptors.
Epinastine Hcl Indications
Indications
Prevention of itching due to allergic conjunctivitis.
Epinastine Hcl Dosage and Administration
Adults and Children
<2yrs: not established. ≥2yrs: 1 drop in each eye twice daily.
Epinastine Hcl Contraindications
Not Applicable
Epinastine Hcl Boxed Warnings
Not Applicable
Epinastine Hcl Warnings/Precautions
Warnings/Precautions
Remove contact lenses; may reinsert 10mins after dosing if eye is not red. Pregnancy (Cat.C). Nursing mothers.
Epinastine Hcl Pharmacokinetics
Elimination
Renal, fecal. Half-life: ~12 hours.
Epinastine Hcl Interactions
Not Applicable
Epinastine Hcl Adverse Reactions
Adverse Reactions
Ocular effects (eg, burning sensation, folliculosis, hyperemia, pruritus), cold symptoms, upper respiratory infections, headache, rhinitis, sinusitis, increased cough, pharyngitis.
Epinastine Hcl Clinical Trials
See Literature
Epinastine Hcl Note
Notes
Formerly known under the brand name Elestat.
Epinastine Hcl Patient Counseling
See Literature
