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Cosopt Pf Generic Name & Formulations
Legal Class
Rx
General Description
Dorzolamide HCl 2%, timolol maleate 0.5%; oph soln; preservative-free.
Pharmacological Class
Carbonic anhydrase inhibitor (sulfonamide) + noncardioselective beta-blocker.
See Also
How Supplied
Cosopt—10mL; Cosopt PF—60 (single-use 0.2mL containers)
Manufacturer
Cosopt Pf Indications
Indications
Open-angle glaucoma or ocular hypertension where β-blocker alone is inadequate.
Cosopt Pf Dosage and Administration
Adults and Children
<2yrs: not recommended. 1 drop twice daily.
Cosopt Pf Contraindications
Contraindications
Asthma or history of asthma. Severe COPD. Sinus bradycardia. 2nd- or 3rd-degree AV block. Overt cardiac failure. Cardiogenic shock.
Cosopt Pf Boxed Warnings
Not Applicable
Cosopt Pf Warnings/Precautions
Warnings/Precautions
Mild-to-moderate COPD or bronchospastic disease, or severe renal impairment: not recommended. Hepatic impairment. Surgery. May mask hypoglycemia or thyrotoxicosis. Myasthenia gravis. Discontinue if ocular effects occur. Soft contact lenses (remove, may reinsert 15 minutes after instillation). Discontinue at 1st sign of cardiac failure. Pregnancy (Cat.C). Nursing mothers: not recommended.
Cosopt Pf Pharmacokinetics
See Literature
Cosopt Pf Interactions
Interactions
Concomitant oral carbonic anhydrase inhibitors or other topical β-blockers: not recommended. May potentiate systemic β-blockers, reserpine, hypoglycemic agents, and mydriatic effects of topical epinephrine. May be potentiated by quinidine. May inhibit renal excretion of basic drugs and promote excretion of acidic drugs. May increase salicylate toxicity (acidosis). Possible conduction defects, left ventricular failure, or hypotension with calcium channel blockers, digoxin. May block epinephrine.
Cosopt Pf Adverse Reactions
Adverse Reactions
Taste perversion; ocular burning, stinging, or itching; conjunctival hyperemia, blurred vision, superficial punctate keratitis; possible systemic effects.
Cosopt Pf Clinical Trials
See Literature
Cosopt Pf Note
Not Applicable
Cosopt Pf Patient Counseling
See Literature
