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Cosopt Generic Name & Formulations
Legal Class
Rx
General Description
Dorzolamide HCl 2%, timolol maleate 0.5%; oph soln; contains benzalkonium chloride.
Pharmacological Class
Carbonic anhydrase inhibitor (sulfonamide) + noncardioselective beta-blocker.
See Also
How Supplied
Cosopt—10mL; Cosopt PF—60 (single-use 0.2mL containers)
Manufacturer
Cosopt Indications
Indications
Open-angle glaucoma or ocular hypertension where β-blocker alone is inadequate.
Cosopt Dosage and Administration
Adults and Children
<2yrs: not recommended. 1 drop twice daily.
Cosopt Contraindications
Contraindications
Asthma or history of asthma. Severe COPD. Sinus bradycardia. 2nd- or 3rd-degree AV block. Overt cardiac failure. Cardiogenic shock.
Cosopt Boxed Warnings
Not Applicable
Cosopt Warnings/Precautions
Warnings/Precautions
Mild-to-moderate COPD or bronchospastic disease, or severe renal impairment: not recommended. Hepatic impairment. Surgery. May mask hypoglycemia or thyrotoxicosis. Myasthenia gravis. Discontinue if ocular effects occur. Soft contact lenses (remove, may reinsert 15 minutes after instillation). Discontinue at 1st sign of cardiac failure. Pregnancy (Cat.C). Nursing mothers: not recommended.
Cosopt Pharmacokinetics
See Literature
Cosopt Interactions
Interactions
Concomitant oral carbonic anhydrase inhibitors or other topical β-blockers: not recommended. May potentiate systemic β-blockers, reserpine, hypoglycemic agents, and mydriatic effects of topical epinephrine. May be potentiated by quinidine. May inhibit renal excretion of basic drugs and promote excretion of acidic drugs. May increase salicylate toxicity (acidosis). Possible conduction defects, left ventricular failure, or hypotension with calcium channel blockers, digoxin. May block epinephrine.
Cosopt Adverse Reactions
Adverse Reactions
Taste perversion; ocular burning, stinging, or itching; conjunctival hyperemia, blurred vision, superficial punctate keratitis; possible systemic effects.
Cosopt Clinical Trials
See Literature
Cosopt Note
Not Applicable
Cosopt Patient Counseling
See Literature
