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Cimerli Generic Name & Formulations
Legal Class
Rx
General Description
Ranibizumab-eqrn 6mg/mL (0.3mg), 10mg/mL (0.5mg); soln for oph intravitreal inj; preservative-free.
Pharmacological Class
Vascular endothelial growth factor (VEGF) inhibitor.
How Supplied
Single-dose vial (2mL)—1
Manufacturer
Generic Availability
NO
Mechanism of Action
Ranibizumab binds to the receptor binding site of active forms of VEGF-A, including the biologically active, cleaved form, VEGF110. The binding to VEGF-A prevents the interaction of VEGF-A with its receptors (VEGFR1 and VEGFR2) on the surface of endothelial cells, reducing endothelial cell proliferation, vascular leakage, and new blood vessel formation.
Cimerli Indications
Indications
Neovascular (wet) age-related macular degeneration (AMD). Macular edema following retinal vein occlusion (RVO). Diabetic macular edema (DME). Diabetic retinopathy (DR). Myopic choroidal neovascularization (mCNV).
Cimerli Dosage and Administration
Adult
Give by intravitreal inj. AMD: 0.5mg once a month (approx. 28 days); or 3 monthly doses followed by less frequent dosing (less effective); or 0.5mg every 3 months after 4 monthly doses (less effective). Monitor regularly. RVO: 0.5mg once a month (approx. 28 days). DME, DR: 0.3mg once a month (approx. 28 days). mCNV: 0.5mg once a month (approx. 28 days) for up to 3 months; may retreat if needed.
Children
Not established.
Nursing Considerations
Procedure should be carried out under controlled aseptic conditions. Give adequate anesthesia and a broad-spectrum microbicide prior to the injection. Each vial or prefilled syringe should be used to treat a single eye. Injection needles should be changed before administering to the other eye.
Cimerli Contraindications
Contraindications
Ocular or periocular infections.
Cimerli Boxed Warnings
Not Applicable
Cimerli Warnings/Precautions
Warnings/Precautions
Monitor intraocular pressure prior to and 30mins after inj. Monitor for perfusion of optic nerve and for infection following the inj (endophthalmitis and retinal detachments possible). Pregnancy. Nursing mothers.
Cimerli Pharmacokinetics
See Literature
Cimerli Interactions
Not Applicable
Cimerli Adverse Reactions
Adverse Reactions
Conjunctival hemorrhage, eye pain, vitreous floaters, increased intraocular pressure, intraocular inflammation; rare: arterial thromboembolic events, fatal events (with DME, DR); possible embryo-fetal toxicity.
Cimerli Clinical Trials
See Literature
Cimerli Note
Not Applicable
Cimerli Patient Counseling
See Literature
