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Apraclonidine 0.5% Generic Name & Formulations
Legal Class
Rx
General Description
Apraclonidine (as HCl) 0.5%; oph soln; contains benzalkonium chloride.
Pharmacological Class
Alpha-2 agonist.
See Also
How Supplied
Soln 0.5%—contact supplier; 1% (0.1mL)—2
Manufacturer
Apraclonidine 0.5% Indications
Indications
Short-term adjunctive therapy to reduce elevated IOP.
Apraclonidine 0.5% Dosage and Administration
Adult
Remove contact lenses; may reinsert 15min after instillation. 1–2 drops into affected eye(s) 3 times daily. Allow at least 5mins between instillation of other oph drugs.
Children
Not established.
Apraclonidine 0.5% Contraindications
Contraindications
Clonidine allergy. Concomitant MAOIs.
Apraclonidine 0.5% Boxed Warnings
Not Applicable
Apraclonidine 0.5% Warnings/Precautions
Warnings/Precautions
Monitor visual fields. Severe uncontrolled cardiovascular disease, hypertension, coronary insufficiency. Recent myocardial infarction. Cerebrovascular disease. Raynaud's disease. Thromboangiitis obliterans. History of vasovagal attack. Discontinue if ocular allergic-like reactions occur. Renal or hepatic impairment: closely monitor cardiovascular parameters. Depression. May mask hypoglycemia. Pregnancy. Nursing mothers (1% soln: discontinue nursing temporarily for 1 day of use).
Apraclonidine 0.5% Pharmacokinetics
See Literature
Apraclonidine 0.5% Interactions
Interactions
See Contraindications. May potentiate CNS depressants (eg, alcohol, barbiturates, opiates, sedatives, anesthetics). Caution with TCAs, β-blockers, antihypertensives, cardiac glycosides, others (eg, clonidine). Concomitant CV drugs: monitor HR, BP periodically.
Apraclonidine 0.5% Adverse Reactions
Adverse Reactions
Hyperemia, pruritus, dry mouth, itching, discomfort, tearing, dizziness, solmnolence, lid edema, blurred vision, foreign body sensation, dry eye, conjunctivitis, discharge, blanching; tachyphylaxis may develop after 1 month; also in post-laser surgery: upper lid elevation, inflammation, nasal decongestion, mydriasis, irregular HR.
Apraclonidine 0.5% Clinical Trials
See Literature
Apraclonidine 0.5% Note
Not Applicable
Apraclonidine 0.5% Patient Counseling
See Literature
