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Xermelo Generic Name & Formulations
Legal Class
Rx
General Description
Telotristat ethyl 250mg; tabs.
Pharmacological Class
Tryptophan hydroxylase inhibitor.
How Supplied
Tabs—84 (monthly case)
Manufacturer
Generic Availability
NO
Xermelo Indications
Indications
In combination with somatostatin analog (SSA) therapy, to treat carcinoid syndrome diarrhea in adults inadequately controlled by SSA therapy.
Xermelo Dosage and Administration
Adult
Take with food. 250mg 3 times daily.
Children
Not established.
Xermelo Contraindications
Not Applicable
Xermelo Boxed Warnings
Not Applicable
Xermelo Warnings/Precautions
Warnings/Precautions
Monitor for constipation and/or severe, persistent, or worsening abdominal pain; discontinue if develops. Moderate and severe hepatic impairment: not recommended. ESRD requiring dialysis: not studied. Pregnancy. Nursing mothers: monitor infant for constipation.
Xermelo Pharmacokinetics
See Literature
Xermelo Interactions
Interactions
May antagonize CYP3A4 (eg, midazolam) or CYP2B6 substrates (eg, bupropion, efavirenz); monitor and consider increasing dose of interacting drug if necessary. Antagonized by short-acting octreotide; if concomitant use is necessary, give dose ≥30mins after Xermelo.
Xermelo Adverse Reactions
Adverse Reactions
Nausea, headache, increased GGT, depression, flatulence, decreased appetite, peripheral edema, pyrexia.
Xermelo Clinical Trials
See Literature
Xermelo Note
Not Applicable
Xermelo Patient Counseling
See Literature
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