Vinorelbine

Risk of myelosuppression. Monitor for infection, and/or fever; obtain CBCs with differentials prior to each dose. Monitor for new or worsening neuropathy. Discontinue if neurotoxicity ≥Grade 2. Interrupt therapy if evidence of pulmonary toxicity or unexplained dyspnea; permanently discontinue if confirmed interstitial pneumonitis or acute respiratory distress syndrome. Hepatic injury or impairment: assess hepatic function prior to and during treatment. Avoid extravasation. Embryo-fetal toxicity. Advise use of effective contraception during and for 6 months (females) and for 3 months (males w. female partners) after last dose. Pregnancy: exclude status prior to initiation. Nursing mothers: not recommended (during and for 9 days after last dose).