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Uvadex Generic Name & Formulations
Legal Class
Rx
General Description
Methoxsalen 20mcg/mL; sterile soln.
Pharmacological Class
Photoactive agent.
How Supplied
Single-use vials (10mL)—12
Manufacturer
Uvadex Indications
Indications
Extracorporeal administration with the UVAR XTS or CELLEX Photopheresis System in the palliative treatment of skin manifestations of cutaneous T-cell lymphoma that is unresponsive to other forms of treatment.
Uvadex Dosage and Administration
Adult
Consult UVAR XTS or CELLEX Photopheresis System Operator's Manual before administering. Give on 2 consecutive days every 4 weeks for minimum of 7 treatment cycles (6 months). Calculate dose per treatment based on treatment volume: Dose (mL) = treatment volume x 0.017. Accelerated treatment schedule: see full labeling.
Children
Not established.
Uvadex Contraindications
Contraindications
Idiosyncratic reactions to psoralen compounds. History of light sensitive disease. Lupus erythematosus. Porphyria cutanea tarda. Erythropoietic protoporphyria. Variegate porphyria. Xeroderma pigmentosum. Albinism. Aphakia.
Uvadex Boxed Warnings
Boxed Warning
Should be used only by trained and experienced physicians.
Uvadex Warnings/Precautions
Warnings/Precautions
Exposure to sun or UV light may cause actinic degeneration, skin burning, cataracts; wear UVA-absorbing, wrap-around sunglasses and cover exposed skin (or use sunblock: SPF ≥15) for 24hrs after treatment. Basal cell carcinomas; monitor. Possible thromboembolic events in treatment of graft-versus-host disease (not approved use). Pregnancy: avoid. Nursing mothers.
Uvadex Pharmacokinetics
See Literature
Uvadex Interactions
Interactions
Increased photosensitivity with anthralin, coal tar, griseofulvin, phenothiazines, nalidixic acid, halogenated salicylanilides, sulfonamides, tetracyclines, thiazides, certain organic staining dyes (eg, methylene blue, toluidine blue, rose bengal, methyl orange).
Uvadex Adverse Reactions
Adverse Reactions
Hypotension secondary to changes in extracorporeal volume; photosensitivity.
Uvadex Clinical Trials
See Literature
Uvadex Note
Not Applicable
Uvadex Patient Counseling
See Literature
