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Thioguanine Generic Name & Formulations
Legal Class
Rx
General Description
Thioguanine 40mg; tabs; scored.
Pharmacological Class
Antimetabolite.
How Supplied
Contact supplier.
Manufacturer
Thioguanine Indications
Indications
Remission induction and remission consolidation treatment of acute nonlymphocytic leukemias. Treatment of the chronic phase of chronic myelogenous leukemia (see full labeling).
Thioguanine Dosage and Administration
Adults and Children
See full labeling. Initially, 2mg/kg per day. If, after 4 weeks, with no improvement, no leukocyte or platelet depression, may increase to 3mg/kg per day. Total daily dose may be given at one time.
Thioguanine Contraindications
Contraindications
Allergy to mercaptopurine.
Thioguanine Boxed Warnings
Not Applicable
Thioguanine Warnings/Precautions
Warnings/Precautions
Not recommended for maintenance therapy or long-term continuous treatments; increased risk of liver toxicity (discontinue if occurs). Pre-existing liver disease. Monitor liver function tests weekly at start of therapy, then monthly thereafter. Thiopurine S-methyltransferase (TPMT) or nucleotide diphosphatase (NUDT15) deficiency (may need to reduce dose to avoid severe bone marrow suppression); consider testing for TPMT and NUDT15 deficiency. Obtain hemoglobin, hematocrit, WBCs with differential, platelets frequently during therapy. Pregnancy (Cat.D); avoid use. Nursing mothers: not recommended.
Thioguanine Pharmacokinetics
See Literature
Thioguanine Interactions
Interactions
Avoid live vaccines (if immunocompromised). Caution with drugs that inhibit TPMT (eg, olsalazine, mesalazine, or sulphasalazine).
Thioguanine Adverse Reactions
Adverse Reactions
Myelosuppression, hyperuricemia, GI upset, anorexia, stomatitis, hepatotoxicity, elevated liver enzymes, jaundice (discontinue if occurs).
Thioguanine Clinical Trials
See Literature
Thioguanine Note
Notes
Formerly known under the brand name Tabloid.
Thioguanine Patient Counseling
See Literature
