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Teniposide Generic Name & Formulations
Legal Class
Rx
General Description
Teniposide 10mg/mL; soln for IV infusion after dilution; contains benzyl alcohol, polyoxy 35 castor oil, dehydrated alcohol.
Pharmacological Class
Topoisomerase inhibitor.
How Supplied
Contact supplier.
Manufacturer
Teniposide Indications
Indications
Refractory childhood acute lymphoblastic leukemia.
Teniposide Dosage and Administration
Adults and Children
See full labeling. Give as slow IV infusion (at least 30–60mins). Patients failing induction therapy with a cytarabine-containing regimen: 165mg/m2 + cytarabine twice weekly for 8 to 9 doses. Refractory to vincristine/prednisone-containing regimen: 250mg/m2 + vincristine weekly for 4 to 8 weeks + oral prednisone for 28 days.
Teniposide Contraindications
Not Applicable
Teniposide Boxed Warnings
Boxed Warning
Should be administered under the supervision of an experienced physician. Severe myelosuppression with resulting infection or bleeding may occur. Hypersensitivity reactions.
Teniposide Warnings/Precautions
Warnings/Precautions
Dose-limiting bone marrow suppression. Monitor for hypersensitivity reactions following infusion; have epinephrine available. Risk of hypotension with rapid IV administration. Hepatic dysfunction. Monitor and obtain CBCs with differential, hemoglobin, platelets, renal and hepatic functions before, during, and after therapy. Down syndrome (use reduced dose). Monitor children with hypoalbuminemia. Avoid extravasation. Pregnancy (Cat.D); avoid use. Nursing mothers: not recommended.
Teniposide Pharmacokinetics
See Literature
Teniposide Interactions
Interactions
Potentiated by tolbutamide, sodium salicylate, and sulfamethizole. Concomitant vincristine sulfate may cause neuropathy. Concomitant antiemetics in patients given high doses of teniposide may increase risk of CNS depression, hypotension.
Teniposide Adverse Reactions
Adverse Reactions
Myelosuppression (leukopenia, neutropenia, thrombocytopenia, anemia), mucositis, GI upset, infection, alopecia, bleeding, rash, fever, hypotension, CNS depression, hypersensitivity reactions (may be fatal).
Teniposide Clinical Trials
See Literature
Teniposide Note
Notes
Formerly known under the brand name Vumon.
Teniposide Patient Counseling
See Literature
