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Proglycem Suspension Generic Name & Formulations
Legal Class
Rx
General Description
Diazoxide 50mg/mL; chocolate-mint flavor; contains alcohol 7.25%.
Pharmacological Class
Nondiuretic benzothiadiazine derivative.
How Supplied
Susp—30mL (w. dropper)
Manufacturer
Proglycem Suspension Indications
Indications
Management of hypoglycemia due to hyperinsulinism associated with: inoperable islet cell adenoma or carcinoma, or extrapancreatic malignancy in adults; leucine sensitivity, islet cell hyperplasia, nesidioblastosis, extrapancreatic malignancy, islet cell adenoma, or adenomatosis in infants and children.
Proglycem Suspension Dosage and Administration
Adults and Children
Individualize. Infants and newborns: Initially 10mg/kg/day divided into 3 equal doses every 8hrs. Usual range: 8–15mg/kg divided into 2–3 equal doses every 8–12hrs. Adults and children: Initially 3mg/kg/day divided into 3 equal doses every 8hrs. Usual range: 3–8mg/kg divided into 2–3 equal doses every 8–12hrs. Refractory hypoglycemia: may require higher dosages. Discontinue if not effective after 2–3 weeks.
Proglycem Suspension Contraindications
Contraindications
Functional hypoglycemia. Thiazide hypersensitivity.
Proglycem Suspension Boxed Warnings
Not Applicable
Proglycem Suspension Warnings/Precautions
Warnings/Precautions
Compromised cardiac reserve: may precipitate CHF. Hyperuricemia. History of gout. Renal impairment: consider reducing dose; evaluate serum electrolyte levels. Newborns with increased bilirubinemia. Monitor for respiratory distress (esp. in those with risk factors); discontinue if pulmonary hypertension is suspected. Monitor blood glucose, BUN, creatinine clearance, hematocrit, platelets, total and differential leukocyte counts, AST, serum uric acid periodically until stabilized. Labor & delivery. Pregnancy (Cat.C). Nursing mothers: not recommended.
Proglycem Suspension Pharmacokinetics
See Literature
Proglycem Suspension Interactions
Interactions
Antihypertensives potentiated. Concomitant coumarin: may need to reduce dose of anticoagulant. Concomitant diphenylhydantoin may result in loss of seizure control. Concomitant thiazides, other diuretics may potentiate hyperglycemic and hyperuricemic effects. Inhibits glucagon-stimulated insulin release and causes false-negative insulin response to glucagon.
Proglycem Suspension Adverse Reactions
Adverse Reactions
Sodium and fluid retention, diabetic ketoacidosis, hyperosmolar nonketotic coma, hirsuitism, hyperglycemia, glycosuria, GI upset, tachycardia, palpitations, increased serum uric acid, thrombocytopenia (may require discontinuation), neutropenia, rash, headache, weakness, malaise.
Proglycem Suspension Clinical Trials
See Literature
Proglycem Suspension Note
Not Applicable
Proglycem Suspension Patient Counseling
See Literature
