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Paclitaxel Generic Name & Formulations
Legal Class
Rx
General Description
Paclitaxel 6mg/mL; soln for IV infusion after dilution; contains polyoxyl 35 castor oil, dehydrated alcohol.
Pharmacological Class
Antimicrotubule agent.
How Supplied
Contact supplier
Manufacturer
Paclitaxel Indications
Indications
Adjuvant treatment of node-positive breast cancer administered sequentially to standard doxorubicin-containing combination chemotherapy. Breast cancer after failure of combination chemotherapy for metastatic disease or relapse within 6 months of adjuvant chemotherapy.
Paclitaxel Dosage and Administration
Adult
See full labeling. Premedicate with corticosteroids, diphenhydramine, H2 antagonists. Breast cancer (node-positive): 175mg/m2 IV over 3 hours every 3 weeks for 4 courses administered sequentially to doxorubicin-containing combination chemotherapy. Breast cancer (after failure of initial chemotherapy for metastatic disease or relapse): 175mg/m2 IV over 3 hours every 3 weeks. Hepatic impairment or neutropenia: see full labeling for dose modifications. Do not treat if neutrophil count <1,500cells/mm3 or platelets <100,000cells/mm3.
Children
Not established.
Paclitaxel Contraindications
Contraindications
Baseline neutrophil count <1,500cells/mm3.
Paclitaxel Boxed Warnings
Boxed Warning
Should be administered under the supervision of an experienced physician. Anaphylaxis and severe hypersensitivity reactions. Bone marrow suppression.
Paclitaxel Warnings/Precautions
Warnings/Precautions
Do frequent peripheral blood cell counts. Hepatic dysfunction. Conduction abnormalities: monitor cardiac function. Avoid extravasation. Pregnancy (Cat.D); avoid use. Nursing mothers: not recommended.
Paclitaxel Pharmacokinetics
See Literature
Paclitaxel Interactions
Interactions
May potentiate or be potentiated by CYP2C8 or CYP3A4 substrates, inducers and/or inhibitors. Potentiated by cisplatin. May potentiate doxorubicin.
Paclitaxel Adverse Reactions
Adverse Reactions
Bone marrow suppression (eg, neutropenia, leukopenia, thrombocytopenia, anemia), inj site reactions, infections, hypotension, bradycardia, hypersensitivity reactions (if severe, do not rechallenge), peripheral neuropathy, myalgia, arthralgia, GI upset, mucositis, alopecia, abnormal ECG, elevated liver enzymes.
Paclitaxel Clinical Trials
See Literature
Paclitaxel Note
Notes
Formerly known under the brand name Taxol.
Paclitaxel Patient Counseling
See Literature
Paclitaxel Generic Name & Formulations
Legal Class
Rx
General Description
Paclitaxel 6mg/mL; soln for IV infusion after dilution; contains polyoxyl 35 castor oil, dehydrated alcohol.
Pharmacological Class
Antimicrotubule agent.
How Supplied
Contact supplier
Manufacturer
Paclitaxel Indications
Indications
First-line therapy (in combination with cisplatin) and subsequent therapy for advanced carcinoma of the ovary.
Paclitaxel Dosage and Administration
Adult
See full labeling. Premedicate with corticosteroids, diphenhydramine, H2 antagonists. Previously untreated ovarian cancer: 175mg/m2 IV over 3 hours + cisplatin every 3 weeks; or 135mg/m2 IV over 24 hours + cisplatin every 3 weeks. Previously treated ovarian cancer: 135mg/m2 or 175mg/m2 IV over 3 hours every 3 weeks. Hepatic impairment or neutropenia: see full labeling for dose modifications. Do not treat if neutrophil count <1,500cells/mm3 or platelets <100,000cells/mm3.
Children
Not established.
Paclitaxel Contraindications
Contraindications
Baseline neutrophil count <1,500cells/mm3.
Paclitaxel Boxed Warnings
Boxed Warning
Should be administered under the supervision of an experienced physician. Anaphylaxis and severe hypersensitivity reactions. Bone marrow suppression.
Paclitaxel Warnings/Precautions
Warnings/Precautions
Do frequent peripheral blood cell counts. Hepatic dysfunction. Conduction abnormalities: monitor cardiac function. Avoid extravasation. Pregnancy (Cat.D); avoid use. Nursing mothers: not recommended.
Paclitaxel Pharmacokinetics
See Literature
Paclitaxel Interactions
Interactions
May potentiate or be potentiated by CYP2C8 or CYP3A4 substrates, inducers and/or inhibitors. Potentiated by cisplatin. May potentiate doxorubicin.
Paclitaxel Adverse Reactions
Adverse Reactions
Bone marrow suppression (eg, neutropenia, leukopenia, thrombocytopenia, anemia), inj site reactions, infections, hypotension, bradycardia, hypersensitivity reactions (if severe, do not rechallenge), peripheral neuropathy, myalgia, arthralgia, GI upset, mucositis, alopecia, abnormal ECG, elevated liver enzymes.
Paclitaxel Clinical Trials
See Literature
Paclitaxel Note
Notes
Formerly known under the brand name Taxol.
Paclitaxel Patient Counseling
See Literature
Paclitaxel Generic Name & Formulations
Legal Class
Rx
General Description
Paclitaxel 6mg/mL; soln for IV infusion after dilution; contains polyoxyl 35 castor oil, dehydrated alcohol.
Pharmacological Class
Antimicrotubule agent.
How Supplied
Contact supplier
Manufacturer
Paclitaxel Indications
Indications
Second-line treatment of AIDS-related Kaposi's sarcoma.
Paclitaxel Dosage and Administration
Adult
See full labeling. Premedicate with corticosteroids, diphenhydramine, H2 antagonists. 135mg/m2 IV over 3 hours every 3 weeks; or 100mg/m2 IV over 3 hours every 2 weeks. Hepatic impairment or neutropenia: see full labeling for dose modifications. Do not treat if neutrophil count <1,000cells/mm3 or platelets <100,000cells/mm3.
Children
Not established.
Paclitaxel Contraindications
Contraindications
Baseline neutrophil count <1,000cells/mm3.
Paclitaxel Boxed Warnings
Boxed Warning
Should be administered under the supervision of an experienced physician. Anaphylaxis and severe hypersensitivity reactions. Bone marrow suppression.
Paclitaxel Warnings/Precautions
Warnings/Precautions
Do frequent peripheral blood cell counts. Hepatic dysfunction. Conduction abnormalities: monitor cardiac function. Avoid extravasation. Pregnancy (Cat.D); avoid use. Nursing mothers: not recommended.
Paclitaxel Pharmacokinetics
See Literature
Paclitaxel Interactions
Interactions
May potentiate or be potentiated by CYP2C8 or CYP3A4 substrates, inducers and/or inhibitors. Potentiated by cisplatin. May potentiate doxorubicin.
Paclitaxel Adverse Reactions
Adverse Reactions
Bone marrow suppression (eg, neutropenia, leukopenia, thrombocytopenia, anemia), inj site reactions, infections, hypotension, bradycardia, hypersensitivity reactions (if severe, do not rechallenge), peripheral neuropathy, myalgia, arthralgia, GI upset, mucositis, alopecia, abnormal ECG, elevated liver enzymes.
Paclitaxel Clinical Trials
See Literature
Paclitaxel Note
Notes
Formerly known under the brand name Taxol.
Paclitaxel Patient Counseling
See Literature
Paclitaxel Generic Name & Formulations
Legal Class
Rx
General Description
Paclitaxel 6mg/mL; soln for IV infusion after dilution; contains polyoxyl 35 castor oil, dehydrated alcohol.
Pharmacological Class
Antimicrotubule agent.
How Supplied
Contact supplier
Manufacturer
Paclitaxel Indications
Indications
First-line treatment of non-small cell lung cancer in combination with cisplatin in patients who are not candidates for potentially curative surgery and/or radiation therapy.
Paclitaxel Dosage and Administration
Adult
See full labeling. Premedicate with corticosteroids, diphenhydramine, H2 antagonists. 135mg/m2 IV over 24 hours + cisplatin every 3 weeks. Hepatic impairment or neutropenia: see full labeling for dose modifications. Do not treat if neutrophil count <1,500cells/mm3 or platelets <100,000cells/mm3.
Children
Not established.
Paclitaxel Contraindications
Contraindications
Baseline neutrophil count <1,500cells/mm3.
Paclitaxel Boxed Warnings
Boxed Warning
Should be administered under the supervision of an experienced physician. Anaphylaxis and severe hypersensitivity reactions. Bone marrow suppression.
Paclitaxel Warnings/Precautions
Warnings/Precautions
Do frequent peripheral blood cell counts. Hepatic dysfunction. Conduction abnormalities: monitor cardiac function. Avoid extravasation. Pregnancy (Cat.D); avoid use. Nursing mothers: not recommended.
Paclitaxel Pharmacokinetics
See Literature
Paclitaxel Interactions
Interactions
May potentiate or be potentiated by CYP2C8 or CYP3A4 substrates, inducers and/or inhibitors. Potentiated by cisplatin. May potentiate doxorubicin.
Paclitaxel Adverse Reactions
Adverse Reactions
Bone marrow suppression (eg, neutropenia, leukopenia, thrombocytopenia, anemia), inj site reactions, infections, hypotension, bradycardia, hypersensitivity reactions (if severe, do not rechallenge), peripheral neuropathy, myalgia, arthralgia, GI upset, mucositis, alopecia, abnormal ECG, elevated liver enzymes.
Paclitaxel Clinical Trials
See Literature
Paclitaxel Note
Notes
Formerly known under the brand name Taxol.
Paclitaxel Patient Counseling
See Literature
