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Matulane Generic Name & Formulations
Legal Class
Rx
General Description
Procarbazine (as HCl) 50mg; caps.
Pharmacological Class
Alkylating agent.
How Supplied
Caps—100
Manufacturer
Matulane Indications
Indications
Stage III and IV Hodgkin's disease as part of the MOPP (nitrogen mustard, vincristine, procarbazine, prednisone) regimen.
Matulane Dosage and Administration
Adult
Initially 2–4mg/kg per day for the first week, then 4–6mg/kg per day until max response is obtained or until WBCs <4,000cells/mm3 or platelets <100,000cells/mm3. Maintain at 1–2mg/kg per day once max response attained. In MOPP regimen: 100mg/m2 daily for 14 days.
Children
Individualize. Initially 50mg/m2 per day for the first week, then 100mg/m2 per day until max response is obtained or leukopenia or thrombocytopenia occurs. Maintain at 50mg/m2 per day once max response attained.
Matulane Contraindications
Contraindications
Inadequate marrow reserve.
Matulane Boxed Warnings
Not Applicable
Matulane Warnings/Precautions
Warnings/Precautions
Discontinue if CNS effects (eg, paresthesias, neuropathies, confusion), leukopenia, thrombocytopenia, hypersensitivity reactions, stomatitis, diarrhea, hemorrhage or bleeding tendencies occur. Hepatic or renal impairment. Obtain baseline CBCs with differential, hemoglobin, hematocrit, reticulocytes, platelets prior to therapy, then monitor at least every 3–4 days. Do renal and hepatic function tests before starting therapy, then repeated weekly. Pregnancy (Cat.D); avoid use. Nursing mothers: not recommended.
Matulane Pharmacokinetics
See Literature
Matulane Interactions
Interactions
Avoid sympathomimetics, tricyclic antidepressants (eg, amitriptyline, imipramine), foods with high tyramine content (eg, wine, yogurt, ripe cheese, bananas). CNS depression with barbiturates, antihistamines, narcotics, hypotensive agents, phenothiazines. Disulfiram-like reactions with alcohol. Separate radiation or other myelosuppressives by at least 1 month (allow for bone marrow recovery).
Matulane Adverse Reactions
Adverse Reactions
Leukopenia, anemia, thrombopenia, GI upset, bleeding tendencies, CNS effects, dysphagia, anorexia, abdominal pain, hypotension, tachycardia, syncope, cough, alopecia, dermatitis, pain, others.
Matulane Clinical Trials
See Literature
Matulane Note
Not Applicable
Matulane Patient Counseling
See Literature
