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Leukeran Generic Name & Formulations
Legal Class
Rx
General Description
Chlorambucil 2mg; tabs.
Pharmacological Class
Alkylating agent.
How Supplied
Tabs—50
Manufacturer
Leukeran Indications
Indications
Palliative treatment of chronic lymphatic (lymphocytic) leukemia and malignant lymphomas (including lymphosarcoma, giant follicular lymphoma, and Hodgkin's disease).
Leukeran Dosage and Administration
Adult
See literature. 0.1–0.2mg/kg per day for 3–6 weeks. Reduce dose if leukocyte or platelet counts fall below normal values and discontinue if more severe depression occurs. Do not give full dose within 4 weeks of radio- or chemotherapy.
Children
Not recommended.
Leukeran Contraindications
Not Applicable
Leukeran Boxed Warnings
Not Applicable
Leukeran Warnings/Precautions
Warnings/Precautions
Compromised bone marrow function. History of seizure disorder or head trauma. Monitor blood weekly (during first 3–6 weeks, do WBC count 3–4 days after each weekly CBC). Discontinue if skin reactions occur. Elderly. Pregnancy (Cat.D), nursing mothers: not recommended.
Leukeran Pharmacokinetics
See Literature
Leukeran Interactions
Interactions
Avoid live vaccines. Myelosuppressives, radiotherapy potentiate antineoplastic effect. Caution with drugs that lower seizure threshold.
Leukeran Adverse Reactions
Adverse Reactions
Bone marrow suppression, seizures, fever, rash, hypersensitivity, urticaria, azoospermia, amenorrhea, sterility, hepato- and pulmonary toxicity, secondary malignancies, GI upset.
Leukeran Clinical Trials
See Literature
Leukeran Note
Not Applicable
Leukeran Patient Counseling
See Literature
