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Ifex Generic Name & Formulations
Legal Class
Rx
General Description
Ifosfamide 1g, 3g; per vial; pwd for IV infusion after reconstitution.
Pharmacological Class
Alkylating agent.
How Supplied
Single-dose vials—1
Manufacturer
Ifex Indications
Indications
Third-line adjunctive treatment of germ cell testicular cancer.
Ifex Dosage and Administration
Adult
Give by slow IV infusion over at least 30 mins. 1.2g/m2 per day for 5 consecutive days; repeat every 3 weeks or after hematological recovery (platelets ≥100000/µL, WBC ≥4000/µL).
Children
Not recommended.
Ifex Contraindications
Contraindications
Urinary outflow obstruction.
Ifex Boxed Warnings
Boxed Warning
Myelosuppression. Neurotoxicity. Urotoxicity.
Ifex Warnings/Precautions
Warnings/Precautions
Risk of myelosuppression, immunosuppression, and infections. Do hematologic profile before each dose; discontinue if WBCs <2000/µL or platelets <50000/µL. Risk of CNS toxicity and other neurotoxic effects. Discontinue if encephalopathy develops. Do urinalysis before each dose, postpone dose if hematuria occurs. Give mesna and at least 2L fluids daily. Active urinary tract infections. Impaired hepatic, renal, or hematopoetic function. Preexisting cardiac disease. May interfere with wound healing. Prior radiation therapy or other cytotoxic agents. Ensure adequate hydration. Pregnancy (Cat.D); avoid. Nursing mothers: not recommended.
Ifex Pharmacokinetics
See Literature
Ifex Interactions
Interactions
Increased risk of myelosuppression with other chemotherapy agents. Caution with drugs acting on the CNS (eg, antiemetics, sedatives, narcotics, antihistamines).
Ifex Adverse Reactions
Adverse Reactions
Alopecia, nausea, vomiting, leukopenia, anemia, CNS toxicity, hematuria, infection, renal or liver dysfunction, phlebitis, fever, urotoxicity (eg, hemorrhagic cystitis), thrombocytopenia, pulmonary toxicity, secondary malignancies.
Ifex Clinical Trials
See Literature
Ifex Note
Not Applicable
Ifex Patient Counseling
See Literature
