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Flutamide Generic Name & Formulations
Legal Class
Rx
General Description
Flutamide 125mg; caps.
Pharmacological Class
Antiandrogen.
How Supplied
Contact supplier.
Manufacturer
Flutamide Indications
Indications
In combination with LHRH agonists (GnRH analogues) in locally confined stage B2–C and stage D2 metastatic prostate carcinoma.
Flutamide Dosage and Administration
Adult
250mg every 8 hrs.
Children
Not applicable.
Flutamide Contraindications
Contraindications
Severe hepatic impairment. ALT ≥2xULN: not recommended.
Flutamide Boxed Warnings
Not Applicable
Flutamide Warnings/Precautions
Warnings/Precautions
Monitor liver function at baseline, monthly for first 4 months, then periodically, and if liver dysfunction occurs; if ALT >2xULN or jaundice occurs, discontinue and monitor closely until resolution. Monitor prostate specific antigen (PSA). Consider monitoring methemoglobin levels in patients susceptible to aniline toxicity (e.g., G6PD deficiency, smokers, hemoglobin M disease). Pregnancy (Cat.D); not for use in women.
Flutamide Pharmacokinetics
See Literature
Flutamide Interactions
Interactions
Monitor warfarin.
Flutamide Adverse Reactions
Adverse Reactions
Diarrhea, hot flashes, loss of libido, impotence, GI disturbances, gynecomastia, rash, edema, hypertension, CNS effects, blood dyscrasias, urine discoloration, liver failure.
Flutamide Clinical Trials
See Literature
Flutamide Note
Notes
Formerly known under the brand name Eulexin.
Flutamide Patient Counseling
See Literature
