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Floxuridine Generic Name & Formulations
Legal Class
Rx
General Description
Floxuridine 500mg/vial; lyophilized pwd for intra-arterial infusion after reconstitution and dilution.
Pharmacological Class
Antimetabolite.
How Supplied
Contact supplier.
Manufacturer
Floxuridine Indications
Indications
Palliative therapy of GI adenocarcinoma with liver metastases in select patients (see literature).
Floxuridine Dosage and Administration
Adult
Continuous arterial infusion 0.1–0.6mg/kg per day. Hepatic artery infusion: 0.4–0.6mg/kg per day. May give until adverse reactions occur; treat as long as response continues. See literature.
Children
Not recommended.
Floxuridine Contraindications
Contraindications
Poor nutritional state. Myelosuppression. Serious infections.
Floxuridine Boxed Warnings
Not Applicable
Floxuridine Warnings/Precautions
Warnings/Precautions
Hospitalize for 1st course. Hepatic or renal dysfunction. History of high-dose pelvic irradiation or alkylation therapy. Monitor blood (esp WBC, platelets). Discontinue for myocardial ischemia, stomatitis or esophagopharyngitis, WBC <3500 or rapidly falling, intractable vomiting, GI ulcer/bleeding, diarrhea, platelets <100000, hemorrhage. Pregnancy (Cat.D); avoid use. Nursing mothers: not recommended.
Floxuridine Pharmacokinetics
See Literature
Floxuridine Interactions
Not Applicable
Floxuridine Adverse Reactions
Adverse Reactions
GI upset, enteritis, stomatitis, localized erythema, myelosuppression, liver dysfunction, GI bleeding/ulcer, duodenitis, gastroenteritis, glossitis, pharyngitis, intra- and extrahepatic biliary sclerosis, acalculous cholecystitis, alopecia, dermatitis, myocardial ischemia, fever, malaise; lab abnormalities (eg, anemia, leukopenia, thrombocytopenia, abnormal PT, total proteins, ESR, ALT/SGOT, bilirubin, lactic dehydrogenase); procedural complications (eg, arterial aneurysm, ischemia, thrombotic events, fibromyositis, thrombophlebitis, hepatic necrosis, abscess).
Floxuridine Clinical Trials
See Literature
Floxuridine Note
Notes
Formerly known under the brand name FUDR.
Floxuridine Patient Counseling
See Literature
