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Emcyt Generic Name & Formulations
Legal Class
Rx
General Description
Estramustine phosphate sodium (prodrug of estradiol) 140mg; caps.
How Supplied
Caps—100
Manufacturer
Emcyt Indications
Indications
Palliative of metastatic, progressive prostate cancer.
Emcyt Dosage and Administration
Adult
Take 1 hour before or 2 hours after meals. 14mg/kg in 3 or 4 divided doses; reevaluate after 30 to 90 days. Continue as long as favorable response maintained.
Children
Not applicable.
Emcyt Contraindications
Contraindications
Active thrombophlebitis or thromboembolic disorders (except when tumor mass caused by thromboembolic phenomenon). Allergy to estradiol, nitrogen mustard.
Emcyt Boxed Warnings
Not Applicable
Emcyt Warnings/Precautions
Warnings/Precautions
History of thrombophlebitis, thrombosis, thromboembolic disorders. Cerebro- or cardiovascular disease. Diabetes. Hypertension. Conditions aggravated by fluid retention. Renal or hepatic dysfunction. Monitor bilirubin and hepatic enzymes during and for 2 months after treatment is discontinued. Metabolic bone diseases associated with hypercalcemia. Use effective contraception.
Emcyt Pharmacokinetics
See Literature
Emcyt Interactions
Interactions
Absorption impaired by calcium.
Emcyt Adverse Reactions
Adverse Reactions
Edema, dyspnea, leg cramps; nausea, diarrhea, GI upset; pruritus, dry skin, easy bruising; breast tenderness and enlargement; lethargy, emotional lability, insomnia; leucopenia; abnormal bilirubin, LDH, SGOT. Thrombosis, MI.
Emcyt Clinical Trials
See Literature
Emcyt Note
Not Applicable
Emcyt Patient Counseling
See Literature
