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Eligard Generic Name & Formulations
Legal Class
Rx
General Description
Leuprolide acetate 7.5mg, 22.5mg, 30mg, 45mg; per inj; ext-rel susp for SC inj.
Pharmacological Class
GnRH analogue.
How Supplied
Single-use kit—1 (with sterile or sterile safety needle)
Manufacturer
Eligard Indications
Indications
Palliative treatment of advanced prostate cancer.
Eligard Dosage and Administration
Adult
Allow product to reach room temperature before using; inject within 30mins of mixing. Use correct formulation. Rotate inj sites. 7.5mg SC once per month; or 22.5mg SC once every 3 months; or 30mg SC once every 4 months; or 45mg SC once every 6 months.
Children
Not established.
Eligard Contraindications
Not Applicable
Eligard Boxed Warnings
Not Applicable
Eligard Warnings/Precautions
Warnings/Precautions
May worsen metastatic vertebral lesions and/or urinary tract obstruction; monitor closely during first few weeks. Increased risk of diabetes, MI, sudden cardiac death, stroke; monitor blood glucose, HbA1c, and for signs/symptoms of CVD during therapy. Risk of QT prolongation in patients with congenital long QT syndrome, CHF, or frequent electrolyte abnormalities. Correct and monitor electrolyte abnormalities; consider monitoring ECGs. Monitor serum testosterone, PSA periodically. Embryo-fetal toxicity. Pregnancy. Nursing mothers: not recommended.
Eligard Pharmacokinetics
See Literature
Eligard Interactions
Interactions
Caution with concomitant drugs known to prolong the QT interval. May interfere with pituitary-gonadal diagnostic tests.
Eligard Adverse Reactions
Adverse Reactions
Malaise, fatigue, hot flashes/sweats, testicular atrophy, local reactions (eg, burning/stinging, pain, erythema, bruising, pruritus); transient worsening of signs/symptoms (eg, bone pain, neuropathy, hematuria, bladder outlet obstruction), spinal cord compression, hyperglycemia, decreased bone density; rare: pituitary apoplexy.
Eligard Clinical Trials
See Literature
Eligard Note
Not Applicable
Eligard Patient Counseling
See Literature
