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Dacarbazine Generic Name & Formulations
Legal Class
Rx
General Description
Dacarbazine 200mg/vial; pwd for IV infusion after reconstitution and dilution; contains mannitol.
Pharmacological Class
Alkylating agent.
How Supplied
Contact supplier
Manufacturer
Dacarbazine Indications
Indications
Second-line therapy for Hodgkin's disease, in combination with other agents.
Dacarbazine Dosage and Administration
Adult
Give by IV infusion. 150mg/m2 daily for 5 days, may repeat every 4 weeks; or 375mg/m2 on day 1, then repeat every 15 days.
Children
Not recommended.
Dacarbazine Contraindications
Not Applicable
Dacarbazine Boxed Warnings
Not Applicable
Dacarbazine Warnings/Precautions
Warnings/Precautions
Monitor CBCs, platelets; may need to discontinue or suspend therapy if hemopoietic toxicity occurs. Pregnancy (Cat.C). Nursing mothers: not recommended.
Dacarbazine Pharmacokinetics
See Literature
Dacarbazine Interactions
Not Applicable
Dacarbazine Adverse Reactions
Adverse Reactions
Myelosuppression (eg, leukopenia, thrombocytopenia, anemia), anorexia, nausea, vomiting, flu-like syndrome, alopecia, facial flushing/paresthesia, inj site reactions, anaphylaxis; rare: hepatic necrosis, photosensitivity reactions.
Dacarbazine Clinical Trials
See Literature
Dacarbazine Note
Notes
Formerly known under the brand name DTIC-Dome.
Dacarbazine Patient Counseling
See Literature
Dacarbazine Generic Name & Formulations
Legal Class
Rx
General Description
Dacarbazine 200mg/vial; pwd for IV infusion after reconstitution and dilution; contains mannitol.
Pharmacological Class
Alkylating agent.
How Supplied
Contact supplier
Manufacturer
Dacarbazine Indications
Indications
Metastatic malignant melanoma.
Dacarbazine Dosage and Administration
Adult
Give by IV infusion. 2–4.5mg/kg/day for 10 days, may repeat every 4 weeks; or 250mg/m2 daily for 5 days, may repeat every 3 weeks.
Children
Not recommended.
Dacarbazine Contraindications
Not Applicable
Dacarbazine Boxed Warnings
Not Applicable
Dacarbazine Warnings/Precautions
Warnings/Precautions
Monitor CBCs, platelets; may need to discontinue or suspend therapy if hemopoietic toxicity occurs. Pregnancy (Cat.C). Nursing mothers: not recommended.
Dacarbazine Pharmacokinetics
See Literature
Dacarbazine Interactions
Not Applicable
Dacarbazine Adverse Reactions
Adverse Reactions
Myelosuppression (eg, leukopenia, thrombocytopenia, anemia), anorexia, nausea, vomiting, flu-like syndrome, alopecia, facial flushing/paresthesia, inj site reactions, anaphylaxis; rare: hepatic necrosis, photosensitivity reactions.
Dacarbazine Clinical Trials
See Literature
Dacarbazine Note
Notes
Formerly known under the brand name DTIC-Dome.
Dacarbazine Patient Counseling
See Literature
