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Bleomycin Generic Name & Formulations
Legal Class
Rx
General Description
Bleomycin 15units/vial, 30units/vial; lyophilized pwd for IM, IV, SC, or intrapleural administration after reconstitution.
Pharmacological Class
Cytotoxic glycopeptide antibiotic.
How Supplied
Contact supplier.
Manufacturer
Bleomycin Indications
Indications
Palliative treatment for squamous cell carcinoma (cervix, vulva).
Bleomycin Dosage and Administration
Adult
0.25–0.5 units/kg IV, IM, or SC weekly or twice weekly. Renal impairment: see literature. Total doses >400 units: increased risk of pulmonary toxicity.
Children
Not recommended.
Bleomycin Contraindications
Not Applicable
Bleomycin Boxed Warnings
Not Applicable
Bleomycin Warnings/Precautions
Warnings/Precautions
Renal impairment. Compromised pulmonary function. Monitor renal function. Elderly. Pregnancy (Cat.D); avoid use. Nursing mothers: not recommended.
Bleomycin Pharmacokinetics
See Literature
Bleomycin Interactions
Interactions
May be potentiated by nephrotoxic drugs.
Bleomycin Adverse Reactions
Adverse Reactions
Erythema, rash, striae, vesiculation, hyperpigmentation, tenderness of the skin, hyperkeratosis, nail changes, alopecia, pruritus, stomatitis; pneumonitis, pulmonary fibrosis, idiosyncratic reaction (hypotension, mental confusion, fever, chills, wheezing).
Bleomycin Clinical Trials
See Literature
Bleomycin Note
Notes
Formerly known under the brand name Blenoxane.
Bleomycin Patient Counseling
See Literature
Bleomycin Generic Name & Formulations
Legal Class
Rx
General Description
Bleomycin 15units/vial, 30units/vial; lyophilized pwd for IM, IV, SC, or intrapleural administration after reconstitution.
Pharmacological Class
Cytotoxic glycopeptide antibiotic.
How Supplied
Contact supplier.
Manufacturer
Bleomycin Indications
Indications
Palliative treatment for squamous cell carcinoma (head and neck).
Bleomycin Dosage and Administration
Adult
0.25–0.5 units/kg IV, IM, or SC weekly or twice weekly. Renal impairment: see literature. Total doses >400 units: increased risk of pulmonary toxicity.
Children
Not recommended.
Bleomycin Contraindications
Not Applicable
Bleomycin Boxed Warnings
Not Applicable
Bleomycin Warnings/Precautions
Warnings/Precautions
Renal impairment. Compromised pulmonary function. Monitor renal function. Elderly. Pregnancy (Cat.D); avoid use. Nursing mothers: not recommended.
Bleomycin Pharmacokinetics
See Literature
Bleomycin Interactions
Interactions
May be potentiated by nephrotoxic drugs.
Bleomycin Adverse Reactions
Adverse Reactions
Erythema, rash, striae, vesiculation, hyperpigmentation, tenderness of the skin, hyperkeratosis, nail changes, alopecia, pruritus, stomatitis; pneumonitis, pulmonary fibrosis, idiosyncratic reaction (hypotension, mental confusion, fever, chills, wheezing).
Bleomycin Clinical Trials
See Literature
Bleomycin Note
Notes
Formerly known under the brand name Blenoxane.
Bleomycin Patient Counseling
See Literature
Bleomycin Generic Name & Formulations
Legal Class
Rx
General Description
Bleomycin 15units/vial, 30units/vial; lyophilized pwd for IM, IV, SC, or intrapleural administration after reconstitution.
Pharmacological Class
Cytotoxic glycopeptide antibiotic.
How Supplied
Contact supplier.
Manufacturer
Bleomycin Indications
Indications
Palliative treatment for lymphomas (Hodgkin's disease, non-Hodgkin's lymphoma).
Bleomycin Dosage and Administration
Adult
Lymphomas: treat with ≤2 units for the first two doses, if no acute reaction occurs, follow regular dosage schedule. Non-Hodgkin's lymphoma: 0.25–0.5 units/kg IV, IM, or SC weekly or twice weekly. Hodgkin's disease: 0.25–0.5 units/kg IV, IM, or SC weekly or twice weekly; after a 50% response, a maintenance dose of 1 unit daily or 5 units weekly IV or IM should be given. Renal impairment: see literature. Total doses >400 units: increased risk of pulmonary toxicity.
Children
Not recommended.
Bleomycin Contraindications
Not Applicable
Bleomycin Boxed Warnings
Not Applicable
Bleomycin Warnings/Precautions
Warnings/Precautions
Renal impairment. Compromised pulmonary function. Monitor renal function. Elderly. Pregnancy (Cat.D); avoid use. Nursing mothers: not recommended.
Bleomycin Pharmacokinetics
See Literature
Bleomycin Interactions
Interactions
May be potentiated by nephrotoxic drugs.
Bleomycin Adverse Reactions
Adverse Reactions
Erythema, rash, striae, vesiculation, hyperpigmentation, tenderness of the skin, hyperkeratosis, nail changes, alopecia, pruritus, stomatitis; pneumonitis, pulmonary fibrosis, idiosyncratic reaction (hypotension, mental confusion, fever, chills, wheezing).
Bleomycin Clinical Trials
See Literature
Bleomycin Note
Notes
Formerly known under the brand name Blenoxane.
Bleomycin Patient Counseling
See Literature
Bleomycin Generic Name & Formulations
Legal Class
Rx
General Description
Bleomycin 15units/vial, 30units/vial; lyophilized pwd for IM, IV, SC, or intrapleural administration after reconstitution.
Pharmacological Class
Cytotoxic glycopeptide antibiotic.
How Supplied
Contact supplier.
Manufacturer
Bleomycin Indications
Indications
Palliative treatment for squamous cell carcinoma (penis), testicular carcinoma (embryonal cell, choriocarcinoma, teratocarcinoma).
Bleomycin Dosage and Administration
Adult
0.25–0.5 units/kg IV, IM, or SC weekly or twice weekly. Renal impairment: see literature. Total doses >400 units: increased risk of pulmonary toxicity.
Children
Not recommended.
Bleomycin Contraindications
Not Applicable
Bleomycin Boxed Warnings
Not Applicable
Bleomycin Warnings/Precautions
Warnings/Precautions
Renal impairment. Compromised pulmonary function. Monitor renal function. Elderly. Pregnancy (Cat.D); avoid use. Nursing mothers: not recommended.
Bleomycin Pharmacokinetics
See Literature
Bleomycin Interactions
Interactions
May be potentiated by nephrotoxic drugs.
Bleomycin Adverse Reactions
Adverse Reactions
Erythema, rash, striae, vesiculation, hyperpigmentation, tenderness of the skin, hyperkeratosis, nail changes, alopecia, pruritus, stomatitis; pneumonitis, pulmonary fibrosis, idiosyncratic reaction (hypotension, mental confusion, fever, chills, wheezing).
Bleomycin Clinical Trials
See Literature
Bleomycin Note
Notes
Formerly known under the brand name Blenoxane.
Bleomycin Patient Counseling
See Literature
Bleomycin Generic Name & Formulations
Legal Class
Rx
General Description
Bleomycin 15units/vial, 30units/vial; lyophilized pwd for IM, IV, SC, or intrapleural administration after reconstitution.
Pharmacological Class
Cytotoxic glycopeptide antibiotic.
How Supplied
Contact supplier.
Manufacturer
Bleomycin Indications
Indications
Sclerosing agent for the treatment of malignant pleural effusion and prevention of recurrent pleural effusions.
Bleomycin Dosage and Administration
Adult
60 units as a single dose bolus intrapleural injection. Renal impairment: see literature.
Children
Not recommended.
Bleomycin Contraindications
Not Applicable
Bleomycin Boxed Warnings
Not Applicable
Bleomycin Warnings/Precautions
Warnings/Precautions
Renal impairment. Compromised pulmonary function. Monitor renal function. Elderly. Pregnancy (Cat.D); avoid use. Nursing mothers: not recommended.
Bleomycin Pharmacokinetics
See Literature
Bleomycin Interactions
Interactions
May be potentiated by nephrotoxic drugs.
Bleomycin Adverse Reactions
Adverse Reactions
Erythema, rash, striae, vesiculation, hyperpigmentation, tenderness of the skin, hyperkeratosis, nail changes, alopecia, pruritus, stomatitis; pneumonitis, pulmonary fibrosis, idiosyncratic reaction (hypotension, mental confusion, fever, chills, wheezing).
Bleomycin Clinical Trials
See Literature
Bleomycin Note
Not Applicable
Bleomycin Patient Counseling
See Literature
