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Aromasin Generic Name & Formulations
Legal Class
Rx
General Description
Exemestane 25mg; tabs.
Pharmacological Class
Aromatase inhibitor.
How Supplied
Tabs—30
Manufacturer
Aromasin Indications
Indications
In postmenopausal women: adjuvant treatment of estrogen-receptor positive early breast cancer after 2–3yrs of tamoxifen therapy to complete a total of 5yrs of hormonal therapy; advanced breast cancer with disease progression after tamoxifen therapy.
Aromasin Dosage and Administration
Adult
Give after a meal. 25mg once daily. Concomitant strong CYP3A4 inducers (see Interactions): 50mg once daily.
Children
Not established.
Aromasin Contraindications
Not Applicable
Aromasin Boxed Warnings
Not Applicable
Aromasin Warnings/Precautions
Warnings/Precautions
Not for treatment in premenopausal women. Osteoporosis; assess bone mineral density (BMD) at start of treatment. Monitor all patients for BMD loss and treat as appropriate. Perform routine assessment of Vit. D levels prior to initiation; supplement if deficient. Hepatic or renal impairment. Embryo-fetal toxicity. Pregnancy. Females of reproductive potential: should undergo pregnancy testing within 7 days prior to initiation; use effective contraception during and for 1 month after final dose. Nursing mothers: not recommended (during and for 1 month after final dose).
Aromasin Pharmacokinetics
See Literature
Aromasin Interactions
Interactions
Antagonized by strong CYP3A4 inducers (eg, rifampicin, phenytoin, carbamazepine, phenobarbital, St. John’s wort).
Aromasin Adverse Reactions
Adverse Reactions
Hot flashes, fatigue, arthralgia, headache, insomnia, increased sweating, nausea, increased appetite; reductions in BMD.
Aromasin Clinical Trials
See Literature
Aromasin Note
Not Applicable
Aromasin Patient Counseling
See Literature
