Alunbrig

Monitor for new or worsening respiratory symptoms esp. during 1^st week of initiation; if occurs, withhold and evaluate for ILD/pneumonitis; reduce dose or permanently discontinue based on severity. Control BP prior to initiation; monitor after 2 weeks and at least monthly thereafter; withhold, reduce dose, or permanently discontinue based on severity. Monitor HR and BP regularly; if symptomatic bradycardia occurs, withhold and evaluate any concomitant drugs known to cause bradycardia; resume at same or reduced dose after resolution; discontinue for life-threatening bradycardia if no contributing concomitant medication identified. Withhold and evaluate for new or worsening visual symptoms of Grade ≥2; reduce dose or permanently discontinue based on severity. Monitor CPK, lipase, and amylase levels during treatment; withhold for Grade 3/4 elevation; resume at same or reduced dose upon recovery to Grade 1 or baseline. Assess fasting serum glucose prior to initiation and periodically thereafter; if not adequately controlled with optimal antihyperglycemics, withhold then consider dose reduction, or permanently discontinue based on severity. Advise to limit sun exposure during and for at least 5 days after treatment discontinuation. Severe hepatic or severe renal impairment. Embryo-fetal toxicity. Pregnancy: exclude status prior to initiation. Advise to use effective non-hormonal contraception during and for at least 4 months (females of reproductive potential) or 3 months (males w. female partners) after final dose. Nursing mothers: not recommended (during and for 1 week after final dose).