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Pitocin Generic Name & Formulations
Legal Class
Rx
General Description
Oxytocin 10Units/mL; IV or IM inj.
How Supplied
Single-dose vial (1mL)—25; Multi-dose vial (10mL)—1, 25
Manufacturer
Pitocin Indications
Indications
Initiation or improvement of uterine contractions in vaginal delivery. Adjunct in abortion. Control of postpartum bleeding.
Pitocin Dosage and Administration
Adult
Induction of labor: individualize. Initially 0.5–1milliunit/minute (see literature); adjust by 1–2 milliunits/minute at 30–60 minute intervals. Usual max at term: 9–10 milliunits/minute. Bleeding: IV, see literature. IM: 10Units after delivery of placenta. Abortion: see literature.
Children
Not applicable.
Pitocin Contraindications
Contraindications
In anteparum use: Cephalopelvic disproportion. Unfavorable fetal position. When surgical intervention necessary. Fetal distress if labor is not imminent. Unsatisfactory progress in presence of adequate uterine activity. Hyperactive or hypertonic uterus. Invasive cervical carcinoma, active herpes genitalis, total placenta previa, vasa previa, cord presentation or prolapse or other cases where vaginal delivery is contraindicated or if predisposition for uterine rupture exists.
Pitocin Boxed Warnings
Boxed Warning
Not for elective induction of labor.
Pitocin Warnings/Precautions
Warnings/Precautions
Use only in presence of qualified personnel. Monitor intrauterine pressure, fetal heart rate, maternal blood pressure.
Pitocin Pharmacokinetics
See Literature
Pitocin Interactions
Interactions
Avoid use within 4 hours of prophylactic vasoconstriction with caudal block anesthesia. Avoid cyclopropane anesthetics.
Pitocin Adverse Reactions
Adverse Reactions
Maternal: anaphylaxis, postpartum or subarachnoid hemorrhage, arrhythmias, fatal afibrinogenemia, nausea, vomiting, premature ventricular contraction, pelvic hematoma, water intoxication, hypersensitivity resulting in uterine hypertonicity, spasm, tetany, or rupture. Fetal: bradycardia, arrhythmias, CNS damage, seizure, low Apgar scores, jaundice, retinal hemorrhage, death.
Pitocin Clinical Trials
See Literature
Pitocin Note
Not Applicable
Pitocin Patient Counseling
See Literature
