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Ovidrel Generic Name & Formulations
Legal Class
Rx
General Description
Choriogonadotropin alfa (r-hCG) 250mcg/0.5mL; liq for SC inj.
How Supplied
Prefilled syringe—1
Manufacturer
Mechanism of Action
Choriogonadotropin alfa stimulates late follicular maturation and resumption of oocyte meiosis, and initiates rupture of the pre-ovulatory ovarian follicle. Choriogonadotropin alfa is an analogue of luteinizing hormone (LH) and binds to the LH/hCG receptor of the granulosa and theca cells of the ovary to effect these changes in the absence of an endogenous LH surge.
Ovidrel Indications
Indications
Induction of final follicular maturation and early luteinization in infertile women as part of an Assisted Reproductive Technology (ART) program. Ovulation induction where infertility is not due to ovarian failure.
Ovidrel Dosage and Administration
Adult
250mg SC one day after last dose of follicle-stimulating agent, if adequate follicular development is evident, and only if there is no evidence of excessive ovarian response (e.g., significant ovarian enlargement, excessive estradiol production, multiple follicular development seen on ultrasound).
Children
Not applicable.
Ovidrel Contraindications
Contraindications
Ovarian enlargement and excessive follicular recruitment while undergoing menotropin therapy. Primary ovarian failure. Uncontrolled thyroid or adrenal dysfunction. Uncontrolled intracranial lesion (eg, pituitary tumor). Abnormal genital bleeding. Ovarian cyst or enlargement. Sex hormone-dependent tumors of reproductive system. Pregnancy.
Ovidrel Boxed Warnings
Not Applicable
Ovidrel Warnings/Precautions
Warnings/Precautions
Do complete gynecological and endocrinological exam first. Cardiac or renal disease. Epilepsy. Migraine. Asthma. Nursing mothers.
Ovidrel Pharmacokinetics
Elimination
Renal. Half-life: 29±6 hours.
Ovidrel Interactions
Not Applicable
Ovidrel Adverse Reactions
Adverse Reactions
Ovarian hyperstimulation syndrome (discontinue if occurs) or enlargement, ascites, pleural effusion, ovarian cyst rupture, abdominal pain, multiple births, arterial thromboembolism, headache, irritability, restlessness, depression, fatigue, edema, local reactions.
Ovidrel Clinical Trials
See Literature
Ovidrel Note
Not Applicable
Ovidrel Patient Counseling
See Literature
