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Methergine Injection Generic Name & Formulations
Legal Class
Rx
General Description
Methylergonovine maleate 0.2mg/mL; amp.
Pharmacological Class
Ergot alkaloid.
See Also
How Supplied
Tabs—7, 12, 28, 100; Inj (1mL amps)—20
Manufacturer
Generic Availability
YES
Methergine Injection Indications
Indications
Following delivery of the placenta, for routine management of uterine atony, hemorrhage, and subinvolution of the uterus. For control of uterine hemorrhage in the second stage of labor following delivery of the anterior shoulder.
Methergine Injection Dosage and Administration
Adult
IM: 0.2mg after delivery of the anterior shoulder, after delivery of the placenta, or during the puerperium; may be repeated as required at intervals of 2–4 hours. IV: 0.2mg given slowly over a period of no less than 60 seconds.
Children
Not established.
Methergine Injection Contraindications
Contraindications
Hypertension. Toxemia. Pregnancy (Cat.C).
Methergine Injection Boxed Warnings
Not Applicable
Methergine Injection Warnings/Precautions
Warnings/Precautions
Avoid intra-arterial, periarterial injection. Coronary artery disease or risk factors; may be more susceptible to developing MI and infarction associated with methylergonovine-induced vasospasm. Sepsis. Obliterative vascular disease. Hepatic or renal disease. 2nd stage of labor. Nursing mothers: not recommended (wait at least 12hrs after last dose before initiating or resuming feeding).
Methergine Injection Pharmacokinetics
See Literature
Methergine Injection Interactions
Interactions
Potentiated by vasoconstrictors, other ergot alkaloids, prostaglandins, beta-blockers. Potent CYP3A4 inhibitors (eg, macrolides, protease inhibitors, reverse transcriptase inhibitors, azole antifungals): not recommended. Use caution with less potent CYP3A4 inhibitors (eg, saquinavir, nefazodone, fluconazole, grapefruit juice, fluoxetine, fluvoxamine, zileuton, clotrimazole). Antagonized by strong inducers of CYP3A4 (eg, nevirapine, rifampicin), anesthetics (eg, halothane, methoxyflurane). Antagonizes glyceryl trinitrate, other antianginal drugs.
Methergine Injection Adverse Reactions
Adverse Reactions
Hypertension associated with seizure and/or headache, hypotension, abdominal pain, GI upset; rare: cardiovascular effects (eg, vasoconstriction, acute MI, transient chest pains).
Methergine Injection Clinical Trials
See Literature
Methergine Injection Note
Not Applicable
Methergine Injection Patient Counseling
See Literature
