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Methergine Generic Name & Formulations
Legal Class
Rx
General Description
Methylergonovine maleate 0.2mg; tabs.
Pharmacological Class
Ergot alkaloid.
See Also
How Supplied
Tabs—7, 12, 28, 100; Inj (1mL amps)—20
Manufacturer
Generic Availability
YES
Methergine Indications
Indications
Following delivery of the placenta, for routine management of uterine atony, hemorrhage, and subinvolution of the uterus. For control of uterine hemorrhage in the second stage of labor following delivery of the anterior shoulder.
Methergine Dosage and Administration
Adult
0.2mg 3–4 times a day in the puerperium for max 1 week.
Children
Not established.
Methergine Contraindications
Contraindications
Hypertension. Toxemia. Pregnancy (Cat.C).
Methergine Boxed Warnings
Not Applicable
Methergine Warnings/Precautions
Warnings/Precautions
Avoid intra-arterial, periarterial injection. Coronary artery disease or risk factors; may be more susceptible to developing MI and infarction associated with methylergonovine-induced vasospasm. Sepsis. Obliterative vascular disease. Hepatic or renal disease. 2nd stage of labor. Nursing mothers: not recommended (wait at least 12hrs after last dose before initiating or resuming feeding).
Methergine Pharmacokinetics
See Literature
Methergine Interactions
Interactions
Potentiated by vasoconstrictors, other ergot alkaloids, prostaglandins, beta-blockers. Potent CYP3A4 inhibitors (eg, macrolides, protease inhibitors, reverse transcriptase inhibitors, azole antifungals): not recommended. Use caution with less potent CYP3A4 inhibitors (eg, saquinavir, nefazodone, fluconazole, grapefruit juice, fluoxetine, fluvoxamine, zileuton, clotrimazole). Antagonized by strong inducers of CYP3A4 (eg, nevirapine, rifampicin), anesthetics (eg, halothane, methoxyflurane). Antagonizes glyceryl trinitrate, other antianginal drugs.
Methergine Adverse Reactions
Adverse Reactions
Hypertension associated with seizure and/or headache, hypotension, abdominal pain, GI upset; rare: cardiovascular effects (eg, vasoconstriction, acute MI, transient chest pains).
Methergine Clinical Trials
See Literature
Methergine Note
Not Applicable
Methergine Patient Counseling
See Literature
