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Lysteda Generic Name & Formulations
Legal Class
Rx
General Description
Tranexamic acid 650mg; tabs.
Pharmacological Class
Antifibrinolytic.
How Supplied
Tabs—30
Manufacturer
Generic Availability
YES
Lysteda Indications
Indications
Cyclic heavy menstrual bleeding.
Lysteda Dosage and Administration
Adult
Treat for up to 5 days during menses. Swallow whole. ≥18yrs: Normal renal function (serum creatinine ≤1.4mg/dL): 1300mg three times daily; Cr >1.4–2.8mg/dL: 1300mg twice daily; Cr >2.8–5.7mg/dL: 1300mg once daily; Cr >5.7mg/dL: 650mg once daily.
Children
Premenarchal: not recommended.
Lysteda Contraindications
Contraindications
Active thromboembolic (eg, DVT, PE, cerebral thrombosis). History or risk of thrombosis or thromboembolism (eg, retinal vein or artery occlusion; thrombogenic valvular disease, thrombogenic cardiac rhythm disease, hypercoagulopathy). Concomitant combination hormonal contraceptives.
Lysteda Boxed Warnings
Not Applicable
Lysteda Warnings/Precautions
Warnings/Precautions
Exclude endometrial pathology prior to initiation. Not for use in postmenopausal women. Discontinue immediately if retinal venous or arterial occlusion occurs. Subarachnoid hemorrhage (cerebral edema/infarction may occur). Acute promyelocytic leukemia treated with oral tretinoin (increased procoagulant effect). Renal impairment. Pregnancy. Nursing mothers.
Lysteda Pharmacokinetics
See Literature
Lysteda Interactions
Interactions
See Contraindications: for hormonal contraceptives. Increased risk of thrombotic events with Factor IX complex concentrates, anti-inhibitor coagulant concentrates, oral tretinoin: use not recommended. Tissue plasminogen activators (tPAs) may decrease efficacy of both tranexamic acid and tPAs.
Lysteda Adverse Reactions
Adverse Reactions
Headache, sinus/nasal symptoms, pain (back, abdomen, musculoskeletal, joint), muscle cramps, migraine, anemia, fatigue; visual/ocular events, severe allergic reaction, ligneous conjunctivitis.
Lysteda Clinical Trials
See Literature
Lysteda Note
Not Applicable
Lysteda Patient Counseling
See Literature
