Femring Generic Name & Formulations
Legal Class
General Description
Pharmacological Class
How Supplied
Manufacturer
Generic Availability
Mechanism of Action
Femring Indications
Indications
Moderate to severe vasomotor symptoms of menopause. Moderate to severe vulvar and vaginal atrophy due to menopause.
Femring Dosage and Administration
Adult
Children
Femring Contraindications
Contraindications
Undiagnosed abnormal genital bleeding. Breast or other estrogen-dependent neoplasms. Active DVT, PE, or history of. Active arterial thromboembolic disease (eg, stroke, MI) or a history of. Hepatic impairment or disease. Protein C, protein S, or antithrombin deficiency, or other thrombophilias. Pregnancy.
Femring Boxed Warnings
Boxed Warning
Femring Warnings/Precautions
Warnings/Precautions
Increased risk of endometrial carcinoma or hyperplasia in women with intact uterus (adding progestin is essential). Not for prevention of cardiovascular disease or dementia. Increased risk of cardiovascular events (eg, MI, stroke, VTE); discontinue if these occur or are suspected. Manage risk factors for cardiovascular disease and venous thromboembolism appropriately. Discontinue at least 4–6 weeks before surgery type associated with increased risk of thromboembolism or during prolonged immobilization. Increased risk of breast or ovarian cancer. Risk of probable dementia in women >65yrs of age. Gallbladder disease. Severe hypercalcemia in breast cancer or bone metastases. Visual abnormalities. Permanently discontinue if papilledema or retinal vascular lesions reveals on exam. Preexisting hypertriglyceridemia. History of cholestatic jaundice. Discontinue if pancreatitis, hypercalcemia, or recurrence of cholestatic jaundice occurs. Monitor thyroid function. Monitor conditions that may predispose to fluid retention. Hypoparathyroidism. Endometriosis. Hereditary angioedema. Asthma. Diabetes. Epilepsy. Migraine. Porphyria. SLE. Hepatic hemangiomas. Narrow vagina, vaginal stenosis, vaginal infections, cervical prolapse, rectoceles and cystoceles increase risk of irritation or ulceration. May use ring while treating vaginal infections. Do initial complete physical and repeat yearly (include Pap smear, mammogram, BP). Reevaluate periodically. Nursing mothers: not recommended.
Femring Pharmacokinetics
Absorption
Mean time to maximum concentration: ~1 hour (range: 0.25–1.5 hours). Average serum estradiol concentration: 40.6 pg/mL after administration of Femring (0.05mg/day estradiol); 76 pg/mL after administration of Femring (0.10 mg/day estradiol).
Distribution
Estrogens are widely distributed in the body and are generally found in higher concentrations in the sex hormone target organs. Estrogens circulate in the blood largely bound to SHBG and albumin.
Elimination
Femring Interactions
Interactions
Femring Adverse Reactions
Adverse Reactions
Femring Clinical Trials
See Literature
Femring Note
Not Applicable
Femring Patient Counseling
See Literature