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Estrace Generic Name & Formulations
Legal Class
Rx
General Description
Estradiol 0.5mg, 1mg, 2mg+; scored tabs; +contains tartrazine.
Pharmacological Class
Estrogen.
How Supplied
Tabs—100
Manufacturer
Generic Availability
YES
Estrace Indications
Indications
Palliative treatment of metastatic breast cancer in select patients (see full labeling).
Estrace Dosage and Administration
Adult
10mg 3 times daily for at least 3 months.
Children
Not applicable.
Estrace Contraindications
Contraindications
Thrombophlebitis. Thromboembolic disorders. Cerebrovascular disorders. Abnormal undiagnosed genital bleeding. Estrogen-depended neoplasias. Liver dysfunction or disease. Pregnancy (Cat. X).
Estrace Boxed Warnings
Boxed Warning
Endometrial cancer. Breast cancer. Cardiovascular disorders. Probable dementia.
Estrace Warnings/Precautions
Warnings/Precautions
Asthma (2mg tabs). Hepatic dysfunction. Conditions aggravated by fluid retention. Cardiovascular disorders, arterial vascular disease, and risks factors (eg, hypertension, diabetes, obesity, SLE). Familial hyperlipoprotenemia. Monitor BP. Discontinue if jaundice occurs and before prolonged immobilization (eg, surgery). Nursing mothers.
Estrace Pharmacokinetics
See Literature
Estrace Interactions
Not Applicable
Estrace Adverse Reactions
Adverse Reactions
See full labeling. GI upset, headache, hypertension, edema, hypercalcemia, gallbladder or thromboembolic disease, gynecomastia, impotence, impaired glucose tolerance.
Estrace Clinical Trials
See Literature
Estrace Note
Not Applicable
Estrace Patient Counseling
See Literature
Estrace Generic Name & Formulations
Legal Class
Rx
General Description
Estradiol 0.5mg, 1mg, 2mg+; scored tabs; +contains tartrazine.
Pharmacological Class
Estrogen.
How Supplied
Tabs—100
Manufacturer
Generic Availability
YES
Estrace Indications
Indications
Moderate-to-severe vasomotor symptoms of menopause. Atrophic vaginitis. Hypoestrogenism. Osteoporosis prevention.
Estrace Dosage and Administration
Adult
Menopause, hypoestrogenism: 1–2mg daily, given cyclically (3 weeks on, 1 week off). Osteoporosis prevention (begin therapy soon after menopause): 0.5mg daily for 3 weeks, then stop for 1 week, then recycle; adjust. Reevaluate periodically.
Children
Not applicable.
Estrace Contraindications
Contraindications
Breast or estrogen-dependent cancer. Thrombophlebitis. Thromboembolic disorders. Undiagnosed abnormal genital bleeding. Pregnancy (Cat.X).
Estrace Boxed Warnings
Boxed Warning
Endometrial cancer. Breast cancer. Cardiovascular disorders. Probable dementia.
Estrace Warnings/Precautions
Warnings/Precautions
Increased risk of endometrial carcinoma or hyperplasia in women with intact uterus (adding progestin is essential). Increased risk of cardiovascular events (eg, MI, stroke, VTE); discontinue if occurs. Manage risk factors for cardiovascular disease and venous thromboembolism appropriately. Breast cancer. Risk of probable dementia in women >65yrs of age. Asthma (2mg tabs). Hepatic dysfunction. Conditions aggravated by fluid retention. Familial hyperlipoproteinemia. Do initial complete physical examination and repeat annually (include BP, mammogram, and PAP smear). Discontinue if jaundice occurs. Nursing mothers.
Estrace Pharmacokinetics
See Literature
Estrace Interactions
Not Applicable
Estrace Adverse Reactions
Adverse Reactions
See full labeling. Mastodynia, breast secretion, uterine bleeding, dysmenorrhea, amenorrhea, GI upset, headache, hypertension, edema, hypercalcemia, gallbladder or thromboembolic disease, skin changes.
Estrace Clinical Trials
See Literature
Estrace Note
Not Applicable
Estrace Patient Counseling
See Literature
Estrace Generic Name & Formulations
Legal Class
Rx
General Description
Estradiol 0.5mg, 1mg, 2mg+; scored tabs; +contains tartrazine.
Pharmacological Class
Estrogen.
How Supplied
Tabs—100
Manufacturer
Generic Availability
YES
Estrace Indications
Indications
Palliative treatment of androgen-dependent advanced prostate cancer.
Estrace Dosage and Administration
Adult
1–2mg 3 times daily.
Children
Not applicable.
Estrace Contraindications
Contraindications
Thrombophlebitis. Thromboembolic disorders. Cerebrovascular disorders. Abnormal undiagnosed genital bleeding. Estrogen-depended neoplasias. Liver dysfunction or disease. Pregnancy (Cat. X).
Estrace Boxed Warnings
Boxed Warning
Endometrial cancer. Breast cancer. Cardiovascular disorders. Probable dementia.
Estrace Warnings/Precautions
Warnings/Precautions
Asthma (2mg tabs). Hepatic dysfunction. Conditions aggravated by fluid retention. Cardiovascular disorders, arterial vascular disease, and risks factors (eg, hypertension, diabetes, obesity, SLE). Familial hyperlipoprotenemia. Monitor BP. Discontinue if jaundice occurs and before prolonged immobilization (eg, surgery). Nursing mothers.
Estrace Pharmacokinetics
See Literature
Estrace Interactions
Not Applicable
Estrace Adverse Reactions
Adverse Reactions
See full labeling. GI upset, headache, hypertension, edema, hypercalcemia, gallbladder or thromboembolic disease, gynecomastia, impotence, impaired glucose tolerance.
Estrace Clinical Trials
See Literature
Estrace Note
Not Applicable
Estrace Patient Counseling
See Literature
