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Endometrin Generic Name & Formulations
Legal Class
Rx
General Description
Progesterone (micronized) 100mg; vaginal insert.
How Supplied
Inserts—21 (w. applicators)
Manufacturer
Endometrin Indications
Indications
To support embryo implantation and early pregnancy by supplementation of corpus luteal function as part of an Assisted Reproductive Technology (ART) treatment program for infertile women.
Endometrin Dosage and Administration
Adult
100mg vaginally 2 or 3 times daily starting at oocyte retrieval for up to 10 weeks total duration. ≥35yrs: efficacy not clearly established; see literature.
Children
Not applicable.
Endometrin Contraindications
Contraindications
Breast carcinoma. Liver dysfunction or disease. Missed abortion. Ectopic pregnancy. Thrombophlebitis or thromboembolic disorders.
Endometrin Boxed Warnings
Not Applicable
Endometrin Warnings/Precautions
Warnings/Precautions
Depression. Discontinue if signs of thrombotic disorders (eg, thrombophlebitis, cerebrovascular disorders, pulmonary embolism, retinal thrombosis) occur. Pregnancy outcome: see literature. Nursing mothers.
Endometrin Pharmacokinetics
See Literature
Endometrin Interactions
Interactions
Concomitant other vaginal products (eg, antifungals): not recommended.
Endometrin Adverse Reactions
Adverse Reactions
GI upset, abdominal pain, post-oocyte retrieval pain, ovarian hyperstimulation syndrome, headache, uterine spasm, vaginal bleeding, fatigue, urinary tract infection.
Endometrin Clinical Trials
See Literature
Endometrin Note
Not Applicable
Endometrin Patient Counseling
See Literature
