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Daysee Generic Name & Formulations
Legal Class
Rx
General Description
Levonorgestrel 0.15mg, ethinyl estradiol 30mcg (84 tabs); ethinyl estradiol 10mcg (7 tabs).
Pharmacological Class
Progestin + estrogen.
How Supplied
Extended-cycle wallets (13-week supply)—1, 2
Manufacturer
Daysee Indications
Indications
Oral contraception.
Daysee Dosage and Administration
Adult
1 tab daily for 91 days; repeat. Use Sunday-start regimen. Take pills in order (84 levonorgestrel + ethinyl estradiol tabs, then 7 ethinyl estradiol tabs).
Children
Premenarchal: not recommended.
Daysee Contraindications
Contraindications
High risk of arterial or venous thrombotic disease (eg, smokers or migraineurs over age 35, history of DVT or PE, cerebrovascular or coronary artery disease, thrombogenic valvular disease, atrial fibrillation, subacute bacterial endocarditis, hypercoagulopathies, uncontrolled hypertension, diabetes with vascular disease, headaches with focal neurologic symptoms). Undiagnosed abnormal genital bleeding. Breast or other estrogen- or progestin-sensitive neoplasms. Hepatic disease or tumors. Pregnancy.
Daysee Boxed Warnings
Boxed Warning
Cigarette smoking increases risk of serious cardiovascular events.
Daysee Warnings/Precautions
Warnings/Precautions
Increased risk of cardiovascular events (eg, MI, stroke, VTE) esp. smokers >35yrs of age. Discontinue if thrombotic event, unexplained visual changes, or jaundice occurs, and at least 4 weeks before through 2 weeks after surgery associated with increased risk of thromboembolism. Gallbladder disease. Diabetes. Prediabetes. Uncontrolled dislipidemias. Hypertriglyceridemia. Pregnancy-related cholestasis. Depression. Hereditary angioedema. Evaluate significant changes in headaches, irregular uterine bleeding, amenorrhea. Monitor blood pressure. Do regular complete physical exams. Nursing mothers: not recommended.
Daysee Pharmacokinetics
See Literature
Daysee Interactions
Interactions
May be antagonized by CYP3A4 or other enzyme inducers (eg, barbiturates, bosentan, carbamazepine, felbamate, griseofulvin, oxcarbazepine, phenytoin, rifampin, St. John’s wort, topiramate); use backup contraception. May be affected by protease inhibitors, NNRTIs, atorvastatin, acetaminophen, ascorbic acid, itraconazole, ketoconazole. May antagonize lamotrigine. May affect laboratory tests (eg, coagulation factors, lipids, glucose tolerance, binding proteins). May need dose adjustment of thyroid hormones.
Daysee Adverse Reactions
Adverse Reactions
Irregular and/or heavy uterine bleeding, weight gain, acne, nausea, breast tenderness, headache, cholelithiasis, pancreatitis, abdominal pain, depression; angioedema, others (see full labeling).
Daysee Clinical Trials
See Literature
Daysee Note
Not Applicable
Daysee Patient Counseling
See Literature
