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Cyclessa Generic Name & Formulations
Legal Class
Rx
General Description
Desogestrel 0.1mg, ethinyl estradiol 25micrograms (7 tabs); desogestrel 0.125mg, ethinyl estradiol 25micrograms (7 tabs); desogestrel 0.15mg, ethinyl estradiol 25micrograms (7 tabs); inert (7 tabs).
Pharmacological Class
Progestin + estrogen.
How Supplied
Pack—1
Manufacturer
Cyclessa Indications
Indications
Oral contraception.
Cyclessa Dosage and Administration
Adult
1 tab daily for 28 days; repeat.
Children
Not applicable.
Cyclessa Contraindications
Contraindications
Thrombophlebitis or thromboembolic disorders. Cerebral vascular or coronary artery disease. Valvular heart disease with thrombogenic complications. Severe hypertension. Diabetes with vascular involvement. Headaches with focal neurologic symptoms. Major surgery with prolonged immobilization. Breast or other estrogen-dependent neoplasms. Undiagnosed abnormal genital bleeding. Cholestatic jaundice of pregnancy or jaundice with prior OC use. Hepatic disease or tumors. Smokers (≥15 cigarettes/day) over age 35. Pregnancy (Cat.X). Concomitant ombitasvir/paritaprevir/ritonavir, with or without dasabuvir.
Cyclessa Boxed Warnings
Boxed Warning
Cigarette smoking increases risk of serious cardiovascular events.
Cyclessa Warnings/Precautions
Warnings/Precautions
Increased risk of cardiovascular events (eg, MI, stroke, VTE) esp. in cigarette smokers >35yrs of age. Discontinue if thrombotic event, unexplained visual changes, jaundice, migraine or other severe headaches occur, and at least 4 weeks before through 2 weeks after surgery associated with increased risk of thromboembolism. Gallbladder disease. Diabetes. Prediabetes. Uncontrolled dyslipidemias. Hypertriglyceridemia. Depression. Fluid rentention. Monitor blood pressure. Do regular complete physical exams. May need barrier contraception with Sunday starts or postpartum use (see full labeling). Nursing mothers: not recommended.
Cyclessa Pharmacokinetics
See Literature
Cyclessa Interactions
Interactions
See Contraindications. ALT elevations with HCV regimen ombitasvir/paritaprevir/ritonavir, with or without dasabuvir; discontinue Cyclessa prior to starting HCV regimen and restart 2wks after completion. May be antagonized by barbiturates, rifampin, phenylbutazone, phenytoin, carbamazepine, felbamate, oxcarbazepine, topiramate, griseofulvin, St. John's wort. May be potentiated by atorvastatin, ascorbic acid, acetaminophen, itraconazole, ketoconazole. May be affected by HIV protease inhibitors. May potentiate cyclosporine, prednisolone, theophylline. May antagonize acetaminophen, temazepam, salicylic acid, morphine, clofibric acid. May affect laboratory tests (eg, coagulation factors, lipids, glucose tolerance, binding proteins).
Cyclessa Adverse Reactions
Adverse Reactions
Nausea, vomiting, breakthrough bleeding, amenorrhea, transient delay of ovulation after discontinuation, edema, chloasma, headache, weight changes, intolerance to contact lenses; serious thromboembolic events, liver disease, hypertension.
Cyclessa Clinical Trials
See Literature
Cyclessa Note
Not Applicable
Cyclessa Patient Counseling
See Literature
