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Crinone Generic Name & Formulations
Legal Class
Rx
General Description
Progesterone (micronized) 8% (90mg/applicatorful); vaginal gel; contains mineral oil.
How Supplied
Prefilled applicators—18
Manufacturer
Crinone Indications
Indications
Progesterone supplementation or replacement as part of an Assisted Reproductive Technology (ART) treatment for infertile women with progesterone deficiency.
Crinone Dosage and Administration
Adult
Supplementation: 1 applicatorful intravaginally once daily. Replacement: 1 applicatorful intravaginally twice daily. If pregnancy occurs, may continue treatment until placental autonomy is achieved (10–12 weeks).
Children
Not applicable.
Crinone Contraindications
Contraindications
Undiagnosed vaginal bleeding. Breast or genital carcinoma. Liver dysfunction or disease. Missed abortion. Thrombophlebitis or thromboembolic disorders.
Crinone Boxed Warnings
Not Applicable
Crinone Warnings/Precautions
Warnings/Precautions
Conditions aggravated by fluid retention. Depression. Include Pap smear with pretreatment exam. Discontinue if signs of thrombotic disorders (eg, thrombophlebitis, cerebrovascular disorders, pulmonary embolism, retinal thrombosis) occur. Pregnancy: see literature. Nursing mothers.
Crinone Pharmacokinetics
Elimination
Renal, fecal. Half-life: 5–20 minutes.
Crinone Interactions
Interactions
Allow at least 6 hours between administration of this and other vaginally-administered products.
Crinone Adverse Reactions
Adverse Reactions
Mastodynia, constipation, somnolence, GI upset, headache, abdominal/perineal pain, nervousness, cramps, nocturia, depression, decreased libido, arthralgia, bloating, pain, vaginal candidiasis/discharge, dizziness, dyspareunia, pruritus genital, allergy, fatigue, urinary tract infection, others.
Crinone Clinical Trials
See Literature
Crinone Note
Not Applicable
Crinone Patient Counseling
See Literature
