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Clindesse Generic Name & Formulations
Legal Class
Rx
General Description
Clindamycin (as phosphate) 2%; vag crm.
Pharmacological Class
Lincosamide.
How Supplied
Prefilled applicator (5g )—1
Manufacturer
Mechanism of Action
Clindamycin inhibits bacterial protein synthesis at the level of the bacterial ribosome. The antibiotic binds preferentially to the 50S ribosomal subunit and affects the process of peptide chain initiation. Although clindamycin phosphate is inactive in vitro, in vivo hydrolysis converts this compound to the antibacterially active clindamycin.
Clindesse Indications
Indications
Bacterial vaginosis.
Clindesse Dosage and Administration
Adult
1 applicatorful intravaginally once.
Children
Not recommended.
Clindesse Contraindications
Contraindications
History of enteritis or colitis.
Clindesse Boxed Warnings
Not Applicable
Clindesse Warnings/Precautions
Warnings/Precautions
Monitor for pseudomembranous colitis. Do not rely on contraceptive diaphragm or condom concurrently or for 5 days after treatment. Do not have vaginal intercourse or use tampons or douches during treatment. Pregnancy (Cat.B). Nursing mothers: not recommended.
Clindesse Pharmacokinetics
Absorption
Peak serum concentration was reached ~20 hours post dosing.
Elimination
Renal. Half-life: ~3 hours.
Clindesse Interactions
Interactions
May potentiate neuromuscular blockers.
Clindesse Adverse Reactions
Adverse Reactions
Fungal vaginosis, vulvovaginal pruritus, headache.
Clindesse Clinical Trials
See Literature
Clindesse Note
Not Applicable
Clindesse Patient Counseling
See Literature
