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Cetrotide Generic Name & Formulations
Legal Class
Rx
General Description
Cetrorelix (as acetate) 0.25mg; per vial; pwd for SC inj after reconstitution.
Pharmacological Class
GnRH antagonist.
How Supplied
Vial—1 (w. diluent, supplies)
Manufacturer
Mechanism of Action
Gonadotropin-releasing hormone (GnRH) induces the production and release of luteinizing hormone (LH) and follicle stimulating hormone (FSH) from the gonadotrophic cells of the anterior pituitary. Due to a positive estradiol (E2) feedback at midcycle, GnRH liberation is enhanced resulting in an LH-surge. This LH-surge induces the ovulation of the dominant follicle, resumption of oocyte meiosis and subsequently luteinization as indicated by rising progesterone levels.
Cetrotide Indications
Indications
Inhibition of premature LH surges in women undergoing controlled ovarian stimulation for in vitro fertilization.
Cetrotide Dosage and Administration
Adult
Give by SC inj into lower abdominal wall during early to mid-follicular phase; see full labeling. 0.25mg daily beginning on stimulation day 5 (morning or evening) or day 6 (morning) and continue until day of hCG administration.
Children
Not applicable.
Cetrotide Contraindications
Contraindications
Pregnancy. Nursing mothers. Severe renal impairment.
Cetrotide Boxed Warnings
Not Applicable
Cetrotide Warnings/Precautions
Warnings/Precautions
Do complete gynecological and endocrinological exam first. Severe allergic conditions.
Cetrotide Pharmacokinetics
Absorption
Mean absolute bioavailability: 85% (after SC administration).
Distribution
Plasma protein bound: 86%.
Elimination
Renal. Half-life: ~62.8 hours.
Cetrotide Interactions
Not Applicable
Cetrotide Adverse Reactions
Adverse Reactions
Ovarian hyperstimulation syndrome, nausea, headache, inj site reactions, elevated enzymes (eg, ALT, alkaline phosphatase); hypersensitivity reactions.
Cetrotide Clinical Trials
See Literature
Cetrotide Note
Not Applicable
Cetrotide Patient Counseling
See Literature
