Addyi

See Contraindications. Increased risk of severe hypotension and syncope with concomitant moderate or strong CYP3A4 inhibitors, if use necessary, discontinue Addyi at least 2 days before starting the CYP3A4 inhibitor; discontinue the CYP3A4 inhibitor for 2 weeks before restarting Addyi. Increased risk of severe hypotension, syncope, and CNS depression with concomitant alcohol (avoid until following day after taking Addyi; advise to wait ≥2hrs before taking Addyi if 1 or 2 standard alcoholic drinks are consumed; skip dose if ≥3 alcoholic drinks are consumed) or concomitant strong CYP2C19 inhibitors (eg, PPIs, SSRIs, antifungals). Increased risk of CNS depression with other CNS depressants (eg, diphenhydramine, opioids, hypnotics, benzodiazepines). Potentiated by weak CYP3A4 inhibitors (eg, oral contraceptives, cimetidine, fluoxetine, ginkgo, resveratrol, ranitidine). Antagonized by CYP3A4 inducers (eg, carbamazepine, phenobarbital, phenytoin, rifabutin, rifampin, rifapentine, St. Johns wort): not recommended. Potentiates digoxin, sirolimus, other P-gp substrates: monitor levels.