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Mephyton Generic Name & Formulations
Legal Class
Rx
General Description
Phytonadione (Vit. K1) 5mg; scored tabs.
How Supplied
Tabs—100
Manufacturer
Mephyton Indications
Indications
Anticoagulant-induced hypoprothrombinemia. Secondary hypoprothrombinemia. Other drug-induced hypoprothrombinemia.
Mephyton Dosage and Administration
Adult
See full labeling. Initially 2.5–25mg as a single dose depending on severity and response; max 50mg.
Children
Not established.
Mephyton Contraindications
Not Applicable
Mephyton Boxed Warnings
Not Applicable
Mephyton Warnings/Precautions
Warnings/Precautions
Does not counteract effects of heparin. Thromboembolism. Hepatic disease. Absorption requires endogenous bile supply. Elderly. Premature infants. Pregnancy. Nursing mothers.
Mephyton Pharmacokinetics
See Literature
Mephyton Interactions
Interactions
May induce temporary resistance to prothrombin-depressing anticoagulants.
Mephyton Adverse Reactions
Adverse Reactions
Transient flushing sensations, peculiar sensations of taste, instances of dizziness, rapid/weak pulse, profuse sweating, brief hypotension, dyspnea, cyanosis; hypersensitivity reactions, hyperbilirubinemia (w. high doses).
Mephyton Clinical Trials
See Literature
Mephyton Note
Not Applicable
Mephyton Patient Counseling
See Literature
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