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Magnesium Sulfate Injection Generic Name & Formulations
Legal Class
Rx
General Description
Magnesium sulfate 500mg/mL; soln for IM inj; or IV use after dilution; contains aluminum.
How Supplied
Contact supplier.
Manufacturer
Magnesium Sulfate Injection Indications
Indications
Magnesium deficiency.
Magnesium Sulfate Injection Dosage and Administration
Adult
Mild deficiency: 1g IM every 6 hours for four doses. Severe deficiency: 250mg/kg IM within a period of 4 hours if necessary; alternatively 5g may be added to one liter of 5% dextrose inj or 0.9% sodium chloride inj for slow IV infusion over a 3-hour period. TPN: usual range: 1–3g (8–24mEq) daily. Severe renal impairment: max 20g in 48 hours.
Children
TPN for infants: usual range: 0.25–1.25g (2–10mEq) daily.
Magnesium Sulfate Injection Contraindications
Contraindications
Heart block. Myocardial damage.
Magnesium Sulfate Injection Boxed Warnings
Not Applicable
Magnesium Sulfate Injection Warnings/Precautions
Warnings/Precautions
Renal impairment. Monitor serum magnesium levels; if repeated doses are given, test knee jerk reflexes before each dose. Have injectable calcium salt readily available to counteract magnesium intoxication. Elderly. Premature neonates. Pregnancy (Cat.D). Nursing mothers.
Magnesium Sulfate Injection Pharmacokinetics
See Literature
Magnesium Sulfate Injection Interactions
Interactions
Additive CNS depressant effects with barbiturates, narcotics, other hypnotics; adjust dose. Potentiates neuromuscular blocking agents. Concomitant cardiac glycosides; use extreme caution, heart block may occur.
Magnesium Sulfate Injection Adverse Reactions
Adverse Reactions
Magnesium intoxication (eg, flushing, sweating, hypotension, depressed reflexes, flaccid paralysis, hypothermia, circulatory collapse, cardiac and CNS depression proceeding to respiratory paralysis.
Magnesium Sulfate Injection Clinical Trials
See Literature
Magnesium Sulfate Injection Note
Notes
Formerly known under the brand name Sulfamag.
Magnesium Sulfate Injection Patient Counseling
See Literature
