Zonisade

Discontinue immediately if hypersensitivity or other serious reactions occur (including severe rash). Evaluate immediately if signs/symptoms of DRESS/multi-organ hypersensitivity develop; discontinue if no alternative etiology. Acute myopia. Secondary angle closure glaucoma. Depression. Suicidal tendencies (monitor). Maintain adequate hydration. Exposure to extreme heat; monitor closely for oligohidrosis and hyperthermia (esp. children). Measure baseline serum bicarbonate and periodically during treatment; consider reducing dose or discontinuing if metabolic acidosis occurs. Measure serum ammonia if signs/symptoms of encephalopathy occur. Avoid abrupt cessation. Avoid in those with renal failure (eGFR <50mL/min). Discontinue if acute renal failure or a clinically significant sustained increase in the creatinine/BUN concentration develops. Renal impairment: titrate more slowly and monitor more frequently. Elderly. Newborns: monitor for metabolic acidosis. Pregnancy: may cause fetal harm. Advise females of reproductive potential to use effective contraception during and for 1 month after discontinuation. Nursing mothers: monitor infants.