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Zarontin Generic Name & Formulations
Legal Class
Rx
General Description
Ethosuximide 250mg; caps.
Pharmacological Class
Succinimide.
See Also
How Supplied
Caps—100; Syrup—pt
Manufacturer
Generic Availability
Caps, syrup (YES)
Zarontin Indications
Indications
Absence seizures.
Zarontin Dosage and Administration
Adult
Initially: 500mg daily. Increase every 4–7 days by 250mg daily according to response; max 1.5g daily in divided doses.
Children
<3yrs: not established. 3–6yrs: initially 250mg daily. >6yrs: initially 500mg daily. Increase both every 4–7 days by 250mg daily according to response; max 1.5g daily in divided doses. Usual maintenance: 20mg/kg/day in divided doses.
Zarontin Contraindications
Not Applicable
Zarontin Boxed Warnings
Not Applicable
Zarontin Warnings/Precautions
Warnings/Precautions
Impaired hepatic or renal function. May precipitate tonic-clonic seizures. Discontinue at 1st sign of rash; consider alternative therapy if signs/symptoms of Stevens-Johnson syndrome occurs. Evaluate immediately if signs/symptoms of DRESS/multi-organ hypersensitivity develop; discontinue if no alternative etiology. Monitor for depression, suicidal ideation, unusual changes in mood/behavior. Monitor CBCs, kidney and liver function periodically. Change dose gradually. Pregnancy. Nursing mothers: not recommended.
Zarontin Pharmacokinetics
See Literature
Zarontin Interactions
Interactions
Monitor phenytoin, phenobarbital, valproic acid, other AEDs.
Zarontin Adverse Reactions
Adverse Reactions
Blood dyscrasias, drowsiness, ataxia, dizziness, headache, GI upset, CNS and psychiatric effects, rash (may be fatal), SLE, DRESS, gingival hyperplasia.
Zarontin Clinical Trials
See Literature
Zarontin Note
Not Applicable
Zarontin Patient Counseling
See Literature
