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Sinemet Generic Name & Formulations
Legal Class
Rx
General Description
Carbidopa, levodopa; 10mg/100mg, 25mg/100mg, 25mg/250mg; tabs.
Pharmacological Class
Dopa-decarboxylase inhibitor + dopamine precursor.
See Also
How Supplied
CR—contact supplier; Tabs—100
Manufacturer
Sinemet Indications
Indications
Parkinsonism.
Sinemet Dosage and Administration
Adult
≥18yrs: Initially one Sinemet 25-100 tab 3 times daily or one Sinemet 10-100 tab 3–4 times daily; increase every 1–2 days up to 2 tabs (of either 25-100 or 10-100 tabs) 4 times daily. If more levodopa is needed, initially one Sinemet 25-250 tab 3–4 times daily; max 8 tabs daily.
Children
<18yrs: not recommended.
Sinemet Contraindications
Contraindications
During or within 14 days of nonselective MAOIs (eg, phenelzine). Narrow-angle glaucoma. Undiagnosed skin lesions. History of melanoma.
Sinemet Boxed Warnings
Not Applicable
Sinemet Warnings/Precautions
Warnings/Precautions
Severe cardiovascular or pulmonary disease. Asthma. Renal, hepatic, or endocrine disorders. History of peptic ulcer or MI with residual arrhythmias. Suicidal tendencies. Psychosis. Orthostatic hypotension. Chronic wide-angle glaucoma. Discontinue levodopa at least 12 hrs before starting Sinemet or Sinemet CR. Sinemet CR not bioequivalent to Sinemet; see literature when switching forms. Monitor renal and liver function, intraocular pressure, blood counts. May stain body fluids. Pregnancy (Cat.C). Nursing mothers.
Sinemet Pharmacokinetics
See Literature
Sinemet Interactions
Interactions
See Contraindications. Orthostatic hypotension with selegiline, antihypertensives. Antagonized by phenothiazines, butyrophenones, risperidone, phenytoin, papaverine. Hypertension, dyskinesia with tricyclic antidepressants. May be antagonized by iron, high protein diets. May cause false (+) urinary ketone test or false (–) urinary glucose (glucose oxidase) test.
Sinemet Adverse Reactions
Adverse Reactions
Dyskinesia, GI upset, hallucinations, confusion, psychological disturbances, depression, dizziness, headache, dream abnormalities, dystonia, cardiac arrhythmias, hypotension, dyspnea, on-off phenomenon, back pain, blepharospasm (may indicate excess dosage), hypertension, anticholinergic effects, anorexia, insomnia, leukopenia, renal and liver function disorders, seizures, neuroleptic malignant syndrome.
Sinemet Clinical Trials
See Literature
Sinemet Note
Not Applicable
Sinemet Patient Counseling
See Literature
