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Selegiline Generic Name & Formulations
Legal Class
Rx
General Description
Selegiline HCl 5mg; caps.
Pharmacological Class
MAO-B inhibitor.
How Supplied
Contact supplier
Manufacturer
Selegiline Indications
Indications
Adjunct to levodopa/carbidopa in Parkinsonism.
Selegiline Dosage and Administration
Adult
5mg at breakfast and at lunch; max 10mg/day. After 2–3 days, levodopa/carbidopa dosage may be reduced by 10–30%; further reductions may be possible later.
Children
Not established.
Selegiline Contraindications
Contraindications
Concomitant meperidine, possibly other opioids.
Selegiline Boxed Warnings
Not Applicable
Selegiline Warnings/Precautions
Warnings/Precautions
Selectivity for MAO type B diminishes at doses over 10mg/day. Pregnancy (Cat.C). Nursing mothers: not recommended.
Selegiline Pharmacokinetics
See Literature
Selegiline Interactions
Interactions
See Contraindications. Avoid concomitant tricyclic antidepressants or selective serotonin reuptake inhibitors (SSRIs). Allow at least 5 weeks (or more if used chronically or at high doses) between fluoxetine discontinuance and 2 weeks between paroxetine or sertraline discontinuance before starting selegiline; allow 2 weeks between selegiline discontinuance before starting tricyclic antidepressants or SSRIs. Caution with tyramine-containing foods and with sympathomimetics.
Selegiline Adverse Reactions
Adverse Reactions
Nausea, dizziness, lightheadedness, syncope, abdominal pain, confusion, vivid dreams, hallucinations, dry mouth, headache.
Selegiline Clinical Trials
See Literature
Selegiline Note
Notes
Formerly known under the brand name Eldepryl.
Selegiline Patient Counseling
See Literature
