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Ropinirole Ext-rel Generic Name & Formulations
Legal Class
Rx
General Description
Ropinirole (as HCl) 2mg, 4mg, 6mg, 8mg, 12mg; ext-rel tabs.
Pharmacological Class
Dopamine agonist (non-ergot).
See Also
How Supplied
Contact supplier
Manufacturer
Ropinirole Ext-rel Indications
Indications
Parkinson's disease.
Ropinirole Ext-rel Dosage and Administration
Adult
Swallow whole. Initially 2mg once daily for 1–2 weeks, then increase by 2mg/day at ≥1-week intervals up to max 24mg/day (for advanced disease: usually up to max 8mg/day; early disease: usually up to max 12mg/day). ESRD on dialysis: initially 2mg once daily; max 18mg/day. Switching from immediate-release ropinirole: give initial dose to closely match total daily dose of immediate-release form. Withdraw gradually over 7 days.
Children
Not established.
Ropinirole Ext-rel Contraindications
Not Applicable
Ropinirole Ext-rel Boxed Warnings
Not Applicable
Ropinirole Ext-rel Warnings/Precautions
Warnings/Precautions
See full labeling. Consider discontinuing if excessive daytime sleepiness or falling asleep during activities occurs. Sleep disorder. Psychotic disorder. Dyskinesia. Severe renal or hepatic impairment. Significant cardiovascular disease; monitor for hypertension and changes in heart rate. Consider dose reduction or discontinuation if urges/compulsive behaviors develop. Monitor for drowsiness or sleepiness, orthostatic hypotension, potential withdrawal symptoms. Fibrotic complications. Avoid abrupt cessation. Elderly. Pregnancy. Nursing mothers.
Ropinirole Ext-rel Pharmacokinetics
See Literature
Ropinirole Ext-rel Interactions
Interactions
May potentiate dopaminergic effects (eg, dyskinesia) with levodopa; consider reducing dose of levodopa. Additive CNS effects when concomitant alcohol, other CNS depressants (eg, benzodiazepines, antipsychotics, antidepressants). May be potentiated by CYP1A2 inhibitors (eg, ciprofloxacin). May be antagonized by CYP1A2 inducers (eg, cigarette smoking) or dopamine antagonists (eg, phenothiazines, butyrophenones, metoclopramide). Adjust ropinirole dose if hormone replacement therapy are added or discontinued.
Ropinirole Ext-rel Adverse Reactions
Adverse Reactions
Early parkinsonism (without levodopa): nausea, somnolence (including sudden sleep onset), dizziness, syncope, asthenia, infection, edema, vomiting, dyspepsia, hypertension, headache, abdominal pain/discomfort, constipation. Advanced disease (with levodopa): also dyskinesia, confusion, hallucinations (esp. in elderly), sweating. Both: withdrawal-emergent hyperpyrexia and confusion.
Ropinirole Ext-rel Clinical Trials
See Literature
Ropinirole Ext-rel Note
Notes
Formerly known under the brand name Requip, Requip XL.
Ropinirole Ext-rel Patient Counseling
See Literature
