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Ropinirole Generic Name & Formulations
Legal Class
Rx
General Description
Ropinirole (as HCl) 0.25mg, 0.5mg, 1mg, 2mg, 3mg, 4mg, 5mg; tabs.
Pharmacological Class
Dopamine agonist (non-ergot).
See Also
How Supplied
Contact supplier
Manufacturer
Ropinirole Indications
Indications
Parkinson's disease.
Ropinirole Dosage and Administration
Adult
Initially 0.25mg 3 times daily, then increase by 0.25mg 3 times daily at 1-week intervals to 1mg 3 times daily to 4th week. May increase by 1.5mg/day at 1-week intervals up to 9mg/day, then by up to 3mg/day at 1-week intervals to max 24mg/day. ESRD on dialysis: initially 0.25mg 3 times daily; max 18mg/day. Withdraw gradually over 7 days.
Children
Not established.
Ropinirole Contraindications
Not Applicable
Ropinirole Boxed Warnings
Not Applicable
Ropinirole Warnings/Precautions
Warnings/Precautions
See full labeling. Consider discontinuing if excessive daytime sleepiness or falling asleep during activities occurs. Sleep disorder. Psychotic disorder. Dyskinesia. Severe renal or hepatic impairment. Significant cardiovascular disease; monitor for hypertension and changes in heart rate. Consider dose reduction or discontinuation if urges/compulsive behaviors develop. Monitor for drowsiness or sleepiness, orthostatic hypotension, potential withdrawal symptoms. Fibrotic complications. Avoid abrupt cessation. Elderly. Pregnancy. Nursing mothers.
Ropinirole Pharmacokinetics
See Literature
Ropinirole Interactions
Interactions
May potentiate dopaminergic effects (eg, dyskinesia) with levodopa; consider reducing dose of levodopa. Additive CNS effects when concomitant alcohol, other CNS depressants (eg, benzodiazepines, antipsychotics, antidepressants). May be potentiated by CYP1A2 inhibitors (eg, ciprofloxacin). May be antagonized by CYP1A2 inducers (eg, cigarette smoking) or dopamine antagonists (eg, phenothiazines, butyrophenones, metoclopramide). Adjust ropinirole dose if hormone replacement therapy are added or discontinued.
Ropinirole Adverse Reactions
Adverse Reactions
Early parkinsonism (without levodopa): nausea, somnolence (including sudden sleep onset), dizziness, syncope, asthenia, infection, edema, vomiting, dyspepsia, hypertension, headache, abdominal pain/discomfort, constipation. Advanced disease (with levodopa): also dyskinesia, confusion, hallucinations (esp. in elderly), sweating. Both: withdrawal-emergent hyperpyrexia and confusion.
Ropinirole Clinical Trials
See Literature
Ropinirole Note
Notes
Formerly known under the brand name Requip, Requip XL.
Ropinirole Patient Counseling
See Literature
Ropinirole Generic Name & Formulations
Legal Class
Rx
General Description
Ropinirole (as HCl) 0.25mg, 0.5mg, 1mg, 2mg, 3mg, 4mg, 5mg; tabs.
Pharmacological Class
Dopamine agonist (non-ergot).
See Also
How Supplied
Tabs—100
Manufacturer
Ropinirole Indications
Indications
Restless legs syndrome.
Ropinirole Dosage and Administration
Adult
Titrate gradually. Take once-daily 1–3 hrs before bedtime. Initially 0.25mg on Days 1 & 2, then 0.5mg on Days 3–7, increase by 0.5mg/day at 1-week intervals to 3mg then may increase to 4mg after 1 week; max 4mg/day. ESRD on dialysis: initially 0.25mg once daily; max 3mg/day. Withdraw gradually.
Children
Not established.
Ropinirole Contraindications
Not Applicable
Ropinirole Boxed Warnings
Not Applicable
Ropinirole Warnings/Precautions
Warnings/Precautions
See full labeling. Consider discontinuing if excessive daytime sleepiness or falling asleep during activities occurs. Sleep disorder. Psychotic disorder. Dyskinesia. Severe renal or hepatic impairment. Significant cardiovascular disease; monitor for hypertension and changes in heart rate. Consider dose reduction or discontinuation if urges/compulsive behaviors develop. Monitor for drowsiness or sleepiness, orthostatic hypotension, potential withdrawal symptoms. Fibrotic complications. Avoid abrupt cessation. Elderly. Pregnancy. Nursing mothers.
Ropinirole Pharmacokinetics
See Literature
Ropinirole Interactions
Interactions
Additive CNS effects when concomitant alcohol, other CNS depressants (eg, benzodiazepines, antipsychotics, antidepressants). Potentiated by ciprofloxacin, possibly other CYP1A2 inhibitors. May be antagonized by dopamine antagonists (eg, phenothiazines, butyrophenones, metoclopramide). Adjust ropinirole dose if estrogens are added or discontinued. Monitor with drugs that induce CYP1A2 (eg, cigarette smoke).
Ropinirole Adverse Reactions
Adverse Reactions
Nausea, vomiting, somnolence, dizziness, fatigue, asthenia, malaise; hallucinations, dyskinesia, withdrawal-emergent hyperpyrexia and confusion, augmentation and early-morning rebound.
Ropinirole Clinical Trials
See Literature
Ropinirole Note
Notes
Formerly known under the brand name Requip, Requip XL.
Ropinirole Patient Counseling
See Literature
