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Rilutek Generic Name & Formulations
Legal Class
Rx
General Description
Riluzole 50mg; tabs.
Pharmacological Class
Benzothiazole.
How Supplied
Tabs—60
Manufacturer
Generic Availability
YES
Rilutek Indications
Indications
Amyotrophic lateral sclerosis (ALS).
Rilutek Dosage and Administration
Adult
Take on an empty stomach. 50mg every 12 hours.
Children
Not established.
Rilutek Contraindications
Not Applicable
Rilutek Boxed Warnings
Not Applicable
Rilutek Warnings/Precautions
Warnings/Precautions
Monitor for hepatic injury. Measure serum aminotransferases every month for first 3 months, and periodically thereafter. If ALT ≥5×ULN develops: do not use; discontinue if elevated bilirubin. Risk of neutropenia; monitor for febrile illness. Discontinue immediately if interstitial lung disease develops. Japanese patients. Elderly. Pregnancy. Nursing mothers.
Rilutek Pharmacokinetics
See Literature
Rilutek Interactions
Interactions
Caution with concomitant hepatotoxic agents (eg, allopurinol, methyldopa, sulfasalazine). May be potentiated by strong or moderate CYP1A2 inhibitors (eg, ciprofloxacin, enoxacin, fluvoxamine, methoxsalen, mexiletine, oral contraceptives, thiabendazole, vemurafenib, zileuton). Possibly antagonized by CYP1A2 inducers.
Rilutek Adverse Reactions
Adverse Reactions
Asthenia, nausea, dizziness, decreased lung function, diarrhea, abdominal pain, vomiting, arthralgia, dry mouth, insomnia, pruritus; abnormal liver function tests, hypersensitivity pneumonitis.
Rilutek Clinical Trials
See Literature
Rilutek Note
Not Applicable
Rilutek Patient Counseling
See Literature
