Share on Facebook
Share on Twitter
Share on LinkedIn
Share by Email
Print
Razadyne Er Generic Name & Formulations
Legal Class
Rx
General Description
Galantamine (as HBr) 8mg, 16mg, 24mg; ext-rel caps.
Pharmacological Class
Reversible acetylcholinesterase inhibitor (benzazepine deriv).
See Also
How Supplied
Tabs, soln—contact supplier; ER caps—30
Manufacturer
Razadyne Er Indications
Indications
Mild to moderate Alzheimer's dementia.
Razadyne Er Dosage and Administration
Adult
Give with AM meal. Initially 8mg/day; if well-tolerated, increase to maintenance dose 16mg/day after minimum of 4 weeks; may attempt further increase to max 24mg/day after minimum of 4 weeks. Re-titrate if interrupted for >3 days. Moderate hepatic or renal impairment (CrCl 9–59mL/min): usual max 16mg/day.
Children
Not established.
Razadyne Er Contraindications
Not Applicable
Razadyne Er Boxed Warnings
Not Applicable
Razadyne Er Warnings/Precautions
Warnings/Precautions
Discontinue at the first sign of skin rash, unless not drug-related; consider alternative therapy if serious skin reactions occur. Conduction disorders (eg, bradycardia, AV block). History of ulcer disease. Bladder outflow obstruction. Asthma. COPD. Seizures. Monitor for active or occult GI bleed, respiratory or neurological effects, and patient's weight. Maintain adequate hydration. Severe hepatic or renal impairment (CrCl <9mL/min): not recommended. Pregnancy. Nursing mothers.
Razadyne Er Pharmacokinetics
See Literature
Razadyne Er Interactions
Interactions
Potentiates neuromuscular blockers (eg, succinylcholine), cholinesterase inhibitors, cholinergic agonists (eg, bethanechol). Antagonizes anticholinergics. Caution with drugs that slow heart rate. May be potentiated by ketoconazole, cimetidine, paroxetine, fluoxetine, erythromycin, possibly others that affect CYP2D6 or CYP3A4. Monitor for GI bleed with NSAIDs.
Razadyne Er Adverse Reactions
Adverse Reactions
Nausea, vomiting, diarrhea, dizziness, headache, decreased appetite, anorexia, weight loss, syncope, bradycardia, heart block, seizures; serious skin reactions (eg, Stevens-Johnson syndrome).
Razadyne Er Clinical Trials
See Literature
Razadyne Er Note
Not Applicable
Razadyne Er Patient Counseling
See Literature
