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Phenytek Generic Name & Formulations
Legal Class
Rx
General Description
Phenytoin sodium, ext-rel 200mg, 300mg; caps.
Pharmacological Class
Hydantoin.
How Supplied
Caps—30, 100
Manufacturer
Phenytek Indications
Indications
Tonic-clonic, psychomotor and neurosurgically induced seizures.
Phenytek Dosage and Administration
Adult
Initially: 100mg 3 times daily. Increase weekly if needed; max 200mg 3 times daily. Once-a-day dosing only with 300mg caps for patients controlled on 300mg daily.
Children
Initially 5mg/kg per day in 2–3 equally divided doses. Increase weekly if needed. Usual maintenance: 4–8mg/kg per day; max 300mg daily.
Phenytek Contraindications
Not Applicable
Phenytek Boxed Warnings
Not Applicable
Phenytek Warnings/Precautions
Warnings/Precautions
Diabetes. Impaired liver function. Change dose gradually. Discontinue if rash develops. Monitor serum levels. Use proper dental hygiene. Hormonal contraception. Porphyria. Elderly. Debilitated. Pregnancy. Nursing mothers: not recommended.
Phenytek Pharmacokinetics
See Literature
Phenytek Interactions
Interactions
Potentiated by acute alcohol ingestion, amiodarone, benzodiazepines (eg, diazepam), chloramphenicol, dicumarol, disulfiram, estrogens, halothane, H2 blockers, isoniazid, methylphenidate, phenothiazines, phenylbutazone, salicylates, succinamides (eg, ethosuximide), sulfonamides, tolbutamide, trazodone, others. Antagonized by chronic alcohol ingestion, carbamazepine, reserpine, others. Antagonizes tricyclic antidepressants, oral anticoagulants, oral contraceptives, estrogens, corticosteroids, doxycycline, digitoxin, furosemide, theophylline, rifampin, quinidine, vitamins D and K, others. Variable effects with phenobarbital, valproic acid, divalproex, others. Absorption decreased by calcium, antacids.
Phenytek Adverse Reactions
Adverse Reactions
Nystagmus, ataxia, slurred speech, decreased coordination, dizziness, GI disturbances, gingival hyperplasia, osteomalacia, blood dyscrasias, lymphadenopathy, hepatic disease, rash, hyperglycemia, SLE, hypertrichosis.
Phenytek Clinical Trials
See Literature
Phenytek Note
Not Applicable
Phenytek Patient Counseling
See Literature
